3wyk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3wyk is ON HOLD Authors: Oki, H., Hayano, Y. Description: Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol...) |
|||
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one== | |
| + | <StructureSection load='3wyk' size='340' side='right'caption='[[3wyk]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3wyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WYK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3KG:3-(1-PHENYL-1H-PYRAZOL-5-YL)-1-[3-(TRIFLUOROMETHYL)PHENYL]PYRIDAZIN-4(1H)-ONE'>3KG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wyk OCA], [https://pdbe.org/3wyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wyk RCSB], [https://www.ebi.ac.uk/pdbsum/3wyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wyk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hayano Y]] | ||
| + | [[Category: Oki H]] | ||
Current revision
Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one
| |||||||||||
