4r8h
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4r8h is ON HOLD Authors: Townsend, P.D., Pohl, E., McLeish, T.C.B., Rodgers, T.L., Glover, L.C., Korhonen, H.J., Wilson, M.R., Hodgson, D.R.W., Cann...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein== |
| - | + | <StructureSection load='4r8h' size='340' side='right'caption='[[4r8h]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r8h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SP1:6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL'>SP1</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8h OCA], [https://pdbe.org/4r8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8h RCSB], [https://www.ebi.ac.uk/pdbsum/4r8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cann MJ]] | ||
| + | [[Category: Glover LC]] | ||
| + | [[Category: Hodgson DRW]] | ||
| + | [[Category: Korhonen HJ]] | ||
| + | [[Category: McLeish TCB]] | ||
| + | [[Category: Pohl E]] | ||
| + | [[Category: Rodgers TL]] | ||
| + | [[Category: Townsend PD]] | ||
| + | [[Category: Wilson MR]] | ||
Current revision
The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein
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