4r8z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4r8z is ON HOLD Authors: Giardina, G., Cutruzzolaa, F., Rinaldo, S., Stelitano, V. Description: Crystal Structure of PA4781 HD-GYP domain from Pseu...) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of PA4781 HD-GYP domain from Pseudomonas aeruginosa at 2.2A resolution showing a bi-metallic Ni ion center== | |
| + | <StructureSection load='4r8z' size='340' side='right'caption='[[4r8z]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4r8z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R8Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8z OCA], [https://pdbe.org/4r8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r8z RCSB], [https://www.ebi.ac.uk/pdbsum/4r8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r8z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDPD2_PSEAE CDPD2_PSEAE] Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP (PubMed:19170727, PubMed:24066157). Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP (PubMed:24066157). Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture (PubMed:19170727). May act preferentially as a pGpG binding protein (PubMed:24066157).<ref>PMID:19170727</ref> <ref>PMID:24066157</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PAO1]] | ||
| + | [[Category: Cutruzzolaa F]] | ||
| + | [[Category: Giardina G]] | ||
| + | [[Category: Rinaldo S]] | ||
| + | [[Category: Stelitano V]] | ||
Current revision
Crystal Structure of PA4781 HD-GYP domain from Pseudomonas aeruginosa at 2.2A resolution showing a bi-metallic Ni ion center
| |||||||||||
