4pid

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:17, 27 September 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor==
==Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor==
-
<StructureSection load='4pid' size='340' side='right' caption='[[4pid]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
+
<StructureSection load='4pid' size='340' side='right'caption='[[4pid]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4pid]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PID OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PID FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4pid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PID FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UQ:N-BENZYL-2-[(Z)-IMINOMETHYL]PYRIMIDINE-5-CARBOXAMIDE'>2UQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nln|1nln]], [[4pie|4pie]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UQ:N-BENZYL-2-[(Z)-IMINOMETHYL]PYRIMIDINE-5-CARBOXAMIDE'>2UQ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenain Adenain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.39 3.4.22.39] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pid OCA], [https://pdbe.org/4pid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pid RCSB], [https://www.ebi.ac.uk/pdbsum/4pid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pid ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pid OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pid RCSB], [http://www.ebi.ac.uk/pdbsum/4pid PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/PRO_ADE02 PRO_ADE02] Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cells cytoskeletal keratins K7 and K18.<ref>PMID:22791715</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 16: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4pid" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adenain]]
+
[[Category: Human adenovirus 2]]
-
[[Category: Altmann, E.]]
+
[[Category: Large Structures]]
-
[[Category: Bernardi, A.]]
+
[[Category: Altmann E]]
-
[[Category: Combrink, K.]]
+
[[Category: Bernardi A]]
-
[[Category: Ellis, D.]]
+
[[Category: Combrink K]]
-
[[Category: Erbel, P.]]
+
[[Category: Ellis D]]
-
[[Category: Grosche, P.]]
+
[[Category: Erbel P]]
-
[[Category: Hughes, N.]]
+
[[Category: Grosche P]]
-
[[Category: Jarousse, N.]]
+
[[Category: Hughes N]]
-
[[Category: Melkko, S.]]
+
[[Category: Jarousse N]]
-
[[Category: Ramage, P.]]
+
[[Category: Mac Sweeney A]]
-
[[Category: Sirockin, F.]]
+
[[Category: Melkko S]]
-
[[Category: Sweeney, A Mac.]]
+
[[Category: Ramage P]]
-
[[Category: Adenain]]
+
[[Category: Sirockin F]]
-
[[Category: Adenovirus]]
+
-
[[Category: Cysteine protease]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Pvic cofactor]]
+
-
[[Category: Virus maturation]]
+

Current revision

Crystal structure of human adenovirus 2 protease with a weak pyrimidine nitrile inhibitor

PDB ID 4pid

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4pid"
Personal tools