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| | <StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''> | | <StructureSection load='2yxr' size='350' side='right' caption='Structure of preprotein translocase subunits SecY (grey), SecE (green), SecG (pink) (PDB entry [[2yxr]])' scene=''> |
| | + | == Function == |
| | + | '''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor<ref>PMID:9489663</ref>. The translocase pathway contains:<br /> |
| | + | *'''SecB''' - a chaperone protein<ref>PMID:9767586</ref> <br /> |
| | + | *'''SecY, SecE, SecG''' or '''Sec61''' an integral membrane complex<br /> |
| | + | *'''SecD, SecF''' - proteins promoting the release of the mature peptide into the periplasm<br /> |
| | + | *'''SecA''' - an ATPase unit<ref>PMID:10617931</ref>.<br /> |
| | | | |
| - | '''Preprotein translocase''' (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor. The translocase pathway contains a chaperone protein – '''SecB'''; an integral membrane complex – '''SecY, SecE, SecG;''' proteins promoting the release of the mature peptide into the periplasm – '''SecD, SecF'''; and ATPase unit - '''SecA'''. For more details see [[SecA PBD motions]].
| + | For more details see [[SecA PBD motions]]. |
| | | | |
| | ==3D structures of preprotein translocase== | | ==3D structures of preprotein translocase== |
| | | | |
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| + | [[Preprotein translocase 3D structures]] |
| | | | |
| - | [[1rh5]], [[1rhz]] – MjPPT SecY + SecE + SecB – ''Methanocaldococcus jannaschii'' <br />
| + | == References == |
| - | [[2akh]], [[2aki]] – EcPPT SecY + SecE + SecG – ''Escherichia coli'' - CryoEM <br />
| + | <references/> |
| - | [[2yxq]], [[2yxr]] – MjPPT SecY + SecE + SecG <br />
| + | </StructureSection> |
| - | [[3mp7]] – PPT SecY + SecE – ''Pyrococcus furiosus'' <br />
| + | |
| - | [[3dkn]] – PPT SecY + SecE + SecG + RNA – dog - CryoEM <br />
| + | |
| - | [[3din]] – TmPPT SecY + SecE + SecG + SecA – ''Thermotoga maritima''<br />
| + | |
| - | [[2zjs]] – TtPPT SecY + SecE + antibody – ''Thermus thermophilus''<br />
| + | |
| - | [[2zqp]] – TtPPT SecY + SecE <br />
| + | |
| - | [[3dl8]] – PPT SecY + SecE + SecA + SecG – ''Aquifex aeolicus'' - CryoEM<br />
| + | |
| - | [[3bo0]], [[3bo1]] – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM<br />
| + | |
| - | [[3kcr]], [[3j45]], [[3j46]] – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
| + | |
| - | [[1vvk]] – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM<br />
| + | |
| - | [[3j01]] – EcPPT SecY + SecE + large ribosomal subunit - CryoEM<br />
| + | |
| - | | + | |
| - | ===PPT SecA=== | + | |
| - | | + | |
| - | [[1m6n]], [[1tf5]], [[2ibm]] – BsPPT SecA – ''Bacillus subtilis'' <br />
| + | |
| - | [[3iqm]], [[3iqy]] – BsPPT SecA (mutant)<br />
| + | |
| - | [[1tm6]] – EcPPT SecA C terminal - NMR<br />
| + | |
| - | [[2ipc]] – TtPPT SecA<br />
| + | |
| - | [[3jux]] – TmPPT SecA<br />
| + | |
| - | [[2fsf]] – EcPPT SecA<br />
| + | |
| - | [[2fsf]] – EcPPT SecA<br />
| + | |
| - | [[3bxz]] – EcPPT SecA dead motor domains (mutant)<br />
| + | |
| - | [[1nl3]] – MtPPT SecA – ''Mycobacterium tuberculosis''<br />
| + | |
| - | | + | |
| - | ''PPT SecA complex''
| + | |
| - | | + | |
| - | [[1m74]], [[1tf2]] – BsPPT SecA + Mg + ADP <br />
| + | |
| - | [[1ozb]] – PPT SecA C terminal + SecB - ''Haemophilus influenzae''<br />
| + | |
| - | [[2fsh]] – EcPPT SecA + AMPPNP<br />
| + | |
| - | [[2fsi]] – EcPPT SecA + ADP<br />
| + | |
| - | [[2fsg]] – EcPPT SecA + ATP<br />
| + | |
| - | [[2vda]] – EcPPT SecA + maltoporin signal peptide - NMR<br />
| + | |
| - | [[3jv2]] – BsPPT SecA + peptide <br />
| + | |
| - | [[1nkt]] – MtPPT SecA + ADP<br />
| + | |
| | | | |
| | [[Category:Topic Page]] | | [[Category:Topic Page]] |
