2mux
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==SUMO2 non-covalently interacts with USP25 and downregulates its activity== | |
| + | <StructureSection load='2mux' size='340' side='right'caption='[[2mux]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mux]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MUX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mux OCA], [https://pdbe.org/2mux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mux RCSB], [https://www.ebi.ac.uk/pdbsum/2mux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mux ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UBP25_HUMAN UBP25_HUMAN] Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains. The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function. | ||
| - | + | ==See Also== | |
| - | + | *[[Thioesterase 3D structures|Thioesterase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Shi L]] | ||
| + | [[Category: Wen Y]] | ||
| + | [[Category: Zhang N]] | ||
Current revision
SUMO2 non-covalently interacts with USP25 and downregulates its activity
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Categories: Homo sapiens | Large Structures | Shi L | Wen Y | Zhang N
