4r2y

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'''Unreleased structure'''
 
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The entry 4r2y is ON HOLD until Paper Publication
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==Crystal structure of APC11 RING domain==
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<StructureSection load='4r2y' size='340' side='right'caption='[[4r2y]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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Authors: Brown, N.G., Watson, E.R., Weissmann, F., Jarvis, M.A., Vanderlinden, R., Grace, C.R.R., Frye, J.J., Dube, P., Qiao, R., Petzold, G., Cho, S.E., Alsharif, O., Bao, J., Zheng, J., Nourse, A., Kurinov, I., Peters, J.M., Stark, H., Schulman, B.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4r2y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R2Y FirstGlance]. <br>
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Description: Crystal structure of isolated RING domain
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.755&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r2y OCA], [https://pdbe.org/4r2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r2y RCSB], [https://www.ebi.ac.uk/pdbsum/4r2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r2y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APC11_HUMAN APC11_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.<ref>PMID:11739784</ref> <ref>PMID:18485873</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alsharif O]]
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[[Category: Bao J]]
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[[Category: Brown NG]]
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[[Category: Cho SE]]
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[[Category: Dube P]]
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[[Category: Frye JJ]]
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[[Category: Grace CRR]]
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[[Category: Jarvis MA]]
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[[Category: Kurinov I]]
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[[Category: Nourse A]]
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[[Category: Peters JM]]
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[[Category: Petzold G]]
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[[Category: Qiao R]]
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[[Category: Schulman BA]]
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[[Category: Stark H]]
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[[Category: Vanderlinden R]]
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[[Category: Watson ER]]
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[[Category: Weissmann F]]
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[[Category: Zheng J]]

Current revision

Crystal structure of APC11 RING domain

PDB ID 4r2y

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