4v06

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(New page: '''Unreleased structure''' The entry 4v06 is ON HOLD Authors: Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft...)
Current revision (10:38, 10 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4v06 is ON HOLD
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==Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain==
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<StructureSection load='4v06' size='340' side='right'caption='[[4v06]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4v06]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4V06 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4v06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v06 OCA], [https://pdbe.org/4v06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4v06 RCSB], [https://www.ebi.ac.uk/pdbsum/4v06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4v06 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
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== Function ==
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[https://www.uniprot.org/uniprot/TPH2_HUMAN TPH2_HUMAN]
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Authors: Kopec, J., Oberholzer, A., Fitzpatrick, F., Newman, J., Tallant, C., Kiyani, W., Shrestha, L., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
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==See Also==
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*[[Hydroxylases 3D structures|Hydroxylases 3D structures]]
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Description: Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith C]]
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[[Category: Bountra C]]
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[[Category: Burgess-Brown N]]
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[[Category: Edwards A]]
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[[Category: Fitzpatrick F]]
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[[Category: Kiyani W]]
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[[Category: Kopec J]]
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[[Category: Newman J]]
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[[Category: Oberholzer A]]
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[[Category: Shrestha L]]
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[[Category: Tallant C]]
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[[Category: Yue WW]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain

PDB ID 4v06

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