This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4uxy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:24, 9 May 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
==Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins==
-
<StructureSection load='4uxy' size='340' side='right' caption='[[4uxy]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
+
<SX load='4uxy' size='340' side='right' viewer='molstar' caption='[[4uxy]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4uxy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UXY FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4uxy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UXY FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uxo|4uxo]], [[4uxp|4uxp]], [[4uxr|4uxr]], [[4uxs|4uxs]], [[4uxt|4uxt]], [[4uy0|4uy0]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uxy RCSB], [http://www.ebi.ac.uk/pdbsum/4uxy PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uxy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uxy OCA], [https://pdbe.org/4uxy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uxy RCSB], [https://www.ebi.ac.uk/pdbsum/4uxy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uxy ProSAT]</span></td></tr>
-
<table>
+
</table>
-
== Disease ==
+
-
[[http://www.uniprot.org/uniprot/KIF5A_HUMAN KIF5A_HUMAN]] Autosomal dominant spastic paraplegia type 10;Autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:12355402</ref> <ref>PMID:15452312</ref> <ref>PMID:16476820</ref> <ref>PMID:16489470</ref> <ref>PMID:18203753</ref> <ref>PMID:18245137</ref> <ref>PMID:18853458</ref> <ref>PMID:21107874</ref>
+
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/KIF5A_HUMAN KIF5A_HUMAN]] Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity). [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
+
[https://www.uniprot.org/uniprot/TBA1B_BOVIN TBA1B_BOVIN] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 4uxy" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Kinesin 3D Structures|Kinesin 3D Structures]]
 +
*[[Tubulin 3D Structures|Tubulin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
-
</StructureSection>
+
</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
-
[[Category: Atherton, J.]]
+
[[Category: Homo sapiens]]
-
[[Category: Farabella, I.]]
+
[[Category: Large Structures]]
-
[[Category: Houdusse, A.]]
+
[[Category: Atherton J]]
-
[[Category: Moores, C.]]
+
[[Category: Farabella I]]
-
[[Category: Rosenfeld, S S.]]
+
[[Category: Houdusse A]]
-
[[Category: Topf, M.]]
+
[[Category: Moores C]]
-
[[Category: Yu, I M.]]
+
[[Category: Rosenfeld SS]]
-
[[Category: Cryo-em]]
+
[[Category: Topf M]]
-
[[Category: Kinesin]]
+
[[Category: Yu IM]]
-
[[Category: Microtubule]]
+
-
[[Category: Transport protein]]
+

Current revision

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

4uxy, resolution 6.50Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4uxy"
Personal tools