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1es7

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[[Image:1es7.gif|left|200px]]
 
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{{Structure
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==COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS==
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|PDB= 1es7 |SIZE=350|CAPTION= <scene name='initialview01'>1es7</scene>, resolution 2.90&Aring;
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<StructureSection load='1es7' size='340' side='right'caption='[[1es7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1es7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ES7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1es7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1es7 OCA], [https://pdbe.org/1es7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1es7 RCSB], [https://www.ebi.ac.uk/pdbsum/1es7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1es7 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN] Induces cartilage and bone formation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/es/1es7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1es7 ConSurf].
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<div style="clear:both"></div>
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'''COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS'''
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==See Also==
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-beta (TGF-beta) superfamily of multifunctional cytokines. BMP-2 can induce ectopic bone and cartilage formation in adult vertebrates and is involved in central steps in early embryonal development in animals. Signaling by these cytokines requires binding of two types of transmembrane serine/threonine receptor kinase chains classified as type I and type II. Here we report the crystal structure of human dimeric BMP-2 in complex with two high affinity BMP receptor IA extracellular domains (BRIAec). The receptor chains bind to the 'wrist' epitopes of the BMP-2 dimer and contact both BMP-2 monomers. No contacts exist between the receptor domains. The model reveals the structural basis for discrimination between type I and type II receptors and the variability of receptor-ligand interactions that is seen in BMP-TGF-beta systems.
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==Disease==
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Known diseases associated with this structure: HFE hemochromatosis, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=112261 112261]], Juvenile polyposis syndrome, infantile form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Polyposis syndrome, hereditary mixed, 2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]], Polyposis, juvenile intestinal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601299 601299]]
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==About this Structure==
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1ES7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ES7 OCA].
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==Reference==
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Crystal structure of the BMP-2-BRIA ectodomain complex., Kirsch T, Sebald W, Dreyer MK, Nat Struct Biol. 2000 Jun;7(6):492-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10881198 10881198]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Dreyer, M K.]]
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[[Category: Dreyer MK]]
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[[Category: Kirsch, T.]]
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[[Category: Kirsch T]]
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[[Category: Sebald, W.]]
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[[Category: Sebald W]]
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[[Category: cytokine receptor]]
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[[Category: protein-protein complex]]
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[[Category: receptor-ligand complex]]
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[[Category: tgf beta superfamily]]
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[[Category: three finger toxin fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:59:35 2008''
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Current revision

COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS

PDB ID 1es7

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