1ew4

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[[Image:1ew4.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY==
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|PDB= 1ew4 |SIZE=350|CAPTION= <scene name='initialview01'>1ew4</scene>, resolution 1.40&Aring;
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<StructureSection load='1ew4' size='340' side='right'caption='[[1ew4]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ew4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1EW4 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ew4 OCA], [https://pdbe.org/1ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/1ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ew4 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CYAY_ECOLI CYAY_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ew/1ew4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ew4 ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY'''
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==See Also==
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*[[Frataxin 3D Structures|Frataxin 3D Structures]]
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__TOC__
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==Overview==
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</StructureSection>
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Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by defects in the FRDA gene, which encodes a mitochondrial protein called frataxin. Frataxin is evolutionarily conserved, with homologs identified in mammals, worms, yeast, and bacteria. The CyaY proteins of gamma-purple bacteria are believed to be closely related to the ancestor of frataxin. In this study, we have determined the crystal structure of the CyaY protein from Escherichia coli at 1.4-A resolution. It reveals a protein fold consisting of a six-stranded antiparallel beta-sheet flanked on one side by two alpha-helices. This fold is likely to be shared by all members of the conserved frataxin family. This study also provides a framework for the interpretation of disease-associated mutations in frataxin and for understanding the possible functions of this protein family.
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==About this Structure==
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1EW4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EW4 OCA].
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==Reference==
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Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family., Cho SJ, Lee MG, Yang JK, Lee JY, Song HK, Suh SW, Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8932-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10908679 10908679]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cho, S.]]
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[[Category: Cho S]]
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[[Category: Lee, J Y.]]
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[[Category: Lee JY]]
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[[Category: Lee, M G.]]
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[[Category: Lee MG]]
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[[Category: Song, H K.]]
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[[Category: Song HK]]
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[[Category: Suh, S W.]]
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[[Category: Suh SW]]
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[[Category: Yang, J K.]]
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[[Category: Yang JK]]
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[[Category: cyay]]
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[[Category: frataxin family]]
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[[Category: friedreich ataxia]]
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[[Category: iron homeostasis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:01:06 2008''
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Current revision

CRYSTAL STRUCTURE OF ESCHERICHIA COLI CYAY PROTEIN REVEALS A NOVEL FOLD FOR THE FRATAXIN FAMILY

PDB ID 1ew4

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