1o0k

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:01, 14 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of the First Parallel DNA Quadruplex-drug Complex==
==Structure of the First Parallel DNA Quadruplex-drug Complex==
-
<StructureSection load='1o0k' size='340' side='right' caption='[[1o0k]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
+
<StructureSection load='1o0k' size='340' side='right'caption='[[1o0k]], [[Resolution|resolution]] 1.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1o0k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O0K FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1o0k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O0K FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.17&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o0k RCSB], [http://www.ebi.ac.uk/pdbsum/1o0k PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
<table>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0k OCA], [https://pdbe.org/1o0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o0k RCSB], [https://www.ebi.ac.uk/pdbsum/1o0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o0k ProSAT]</span></td></tr>
-
<div style="background-color:#fffaf0;">
+
</table>
-
== Publication Abstract from PubMed ==
+
-
The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
+
-
 
+
-
Structure of the first parallel DNA quadruplex-drug complex.,Clark GR, Pytel PD, Squire CJ, Neidle S J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:12670225<ref>PMID:12670225</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Clark, G R.]]
+
[[Category: Large Structures]]
-
[[Category: Neidle, S.]]
+
[[Category: Clark GR]]
-
[[Category: Pytel, P D.]]
+
[[Category: Neidle S]]
-
[[Category: Squire, C J.]]
+
[[Category: Pytel PD]]
-
[[Category: Dna]]
+
[[Category: Squire CJ]]
-
[[Category: G-4 quadruplex drug complex]]
+
-
[[Category: Parallel quadruplex]]
+

Current revision

Structure of the First Parallel DNA Quadruplex-drug Complex

PDB ID 1o0k

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1o0k"
Personal tools