1ms6

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==Dipeptide Nitrile Inhibitor Bound to Cathepsin S.==
==Dipeptide Nitrile Inhibitor Bound to Cathepsin S.==
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<StructureSection load='1ms6' size='340' side='right' caption='[[1ms6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='1ms6' size='340' side='right'caption='[[1ms6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MS6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ms6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MS6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BLN:MORPHOLINE-4-CARBOXYLIC+ACID+[1S-(2-BENZYLOXY-1R-CYANO-ETHYLCARBAMOYL)-3-METHYL-BUTYL]AMIDE'>BLN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ms6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ms6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ms6 OCA], [https://pdbe.org/1ms6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ms6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ms6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ms6 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1ms6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ms6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 1ms6" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin S]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bekkali, Y.]]
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[[Category: Large Structures]]
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[[Category: Brown, M L.]]
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[[Category: Bekkali Y]]
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[[Category: Crane, K.]]
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[[Category: Brown ML]]
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[[Category: Cywin, C L.]]
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[[Category: Crane K]]
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[[Category: Davidson, W.]]
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[[Category: Cywin CL]]
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[[Category: DeTuri, M.]]
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[[Category: Davidson W]]
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[[Category: Emmanuel, M J.]]
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[[Category: DeTuri M]]
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[[Category: Freeman, D M.]]
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[[Category: Emmanuel MJ]]
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[[Category: Frye, L L.]]
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[[Category: Freeman DM]]
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[[Category: Giradot, M.]]
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[[Category: Frye LL]]
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[[Category: Grygon, C A.]]
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[[Category: Giradot M]]
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[[Category: Hao, M H.]]
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[[Category: Grygon CA]]
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[[Category: Hopkins, J L.]]
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[[Category: Hao MH]]
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[[Category: Hrapchak, M.]]
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[[Category: Hopkins JL]]
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[[Category: Labadia, M E.]]
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[[Category: Hrapchak M]]
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[[Category: McNeil, D.]]
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[[Category: Labadia ME]]
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[[Category: Morwick, T.]]
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[[Category: McNeil D]]
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[[Category: Pav, S.]]
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[[Category: Morwick T]]
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[[Category: Spero, D M.]]
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[[Category: Pav S]]
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[[Category: Thomson, D S.]]
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[[Category: Spero DM]]
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[[Category: Wang, Y.]]
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[[Category: Thomson DS]]
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[[Category: Ward, Y D.]]
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[[Category: Wang Y]]
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[[Category: White, D.]]
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[[Category: Ward YD]]
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[[Category: Zindell, R.]]
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[[Category: White D]]
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[[Category: Cathepsin]]
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[[Category: Zindell R]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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Current revision

Dipeptide Nitrile Inhibitor Bound to Cathepsin S.

PDB ID 1ms6

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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