1k9g

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==Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2==
==Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2==
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<StructureSection load='1k9g' size='340' side='right' caption='[[1k9g]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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<StructureSection load='1k9g' size='340' side='right'caption='[[1k9g]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1k9g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K9G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1k9g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K9G FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DR1:5-METHYL-5H-INDOLO[3,2-B]QUINOLINE'>DR1</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k9g RCSB], [http://www.ebi.ac.uk/pdbsum/1k9g PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DR1:5-METHYL-5H-INDOLO[3,2-B]QUINOLINE'>DR1</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9g OCA], [https://pdbe.org/1k9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k9g RCSB], [https://www.ebi.ac.uk/pdbsum/1k9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9g ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
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</table>
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== Publication Abstract from PubMed ==
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Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)(2) in a base-stacking intercalation mode. This is the first DNA intercalator complex, from approximately 90 solved by X-ray crystallography, to bind a nonalternating (pyrimidine-pyrimidine) DNA sequence. The asymmetry of the drug induces a perfect stacking with the asymmetric site, allowing for the stability of the complex in the absence of hydrogen bonding interactions. The crystal structure of this antimalarial drug-DNA complex provides evidence for the first nonalternating intercalation and, as such, provides a basis for the design of new anticancer or antimalarial drugs.
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The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.,Lisgarten JN, Coll M, Portugal J, Wright CW, Aymami J Nat Struct Biol. 2002 Jan;9(1):57-60. PMID:11731803<ref>PMID:11731803</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aymami, J.]]
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[[Category: Large Structures]]
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[[Category: Coll, M.]]
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[[Category: Aymami J]]
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[[Category: Lisgarten, J N.]]
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[[Category: Coll M]]
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[[Category: Portugal, J.]]
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[[Category: Lisgarten JN]]
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[[Category: Wright, C W.]]
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[[Category: Portugal J]]
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[[Category: Dna]]
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[[Category: Wright CW]]
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[[Category: Dna intercalator complex]]
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Current revision

Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2

PDB ID 1k9g

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