This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1pqh
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Serine 25 to Threonine mutation of aspartate decarboxylase== | ==Serine 25 to Threonine mutation of aspartate decarboxylase== | ||
| - | <StructureSection load='1pqh' size='340' side='right' caption='[[1pqh]], [[Resolution|resolution]] 1.29Å' scene=''> | + | <StructureSection load='1pqh' size='340' side='right'caption='[[1pqh]], [[Resolution|resolution]] 1.29Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1pqh]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1pqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PQH FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.29Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=MLA:MALONIC+ACID'>MLA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pqh OCA], [https://pdbe.org/1pqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pqh RCSB], [https://www.ebi.ac.uk/pdbsum/1pqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pqh ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | <tr | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/PAND_ECOLI PAND_ECOLI] Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.<ref>PMID:6767707</ref> | |
| - | <table> | + | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/1pqh_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pq/1pqh_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pqh ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 28: | Line 28: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1pqh" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Aspartate decarboxylase|Aspartate decarboxylase]] | + | *[[Aspartate decarboxylase 3D structures|Aspartate decarboxylase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Aspartate 1-decarboxylase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Abell | + | [[Category: Large Structures]] |
| - | [[Category: Blundell | + | [[Category: Abell C]] |
| - | [[Category: Chirgadze | + | [[Category: Blundell TL]] |
| - | [[Category: Kilkenny | + | [[Category: Chirgadze DY]] |
| - | [[Category: Lobley | + | [[Category: Kilkenny ML]] |
| - | [[Category: Matak-Vinkovic | + | [[Category: Lobley CMC]] |
| - | [[Category: Schmitzberger | + | [[Category: Matak-Vinkovic D]] |
| - | [[Category: Smith | + | [[Category: Schmitzberger F]] |
| - | [[Category: Vinkovic | + | [[Category: Smith AG]] |
| - | [[Category: Webb | + | [[Category: Vinkovic M]] |
| - | [[Category: Witty | + | [[Category: Webb ME]] |
| - | + | [[Category: Witty M]] | |
| - | + | ||
| - | + | ||
Current revision
Serine 25 to Threonine mutation of aspartate decarboxylase
| |||||||||||
