1oqn
From Proteopedia
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==Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)== | ==Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)== | ||
- | <StructureSection load='1oqn' size='340' side='right' caption='[[1oqn]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='1oqn' size='340' side='right'caption='[[1oqn]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[1oqn]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1oqn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQN FirstGlance]. <br> |
- | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>< | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
- | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr> |
- | <table> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqn OCA], [https://pdbe.org/1oqn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqn RCSB], [https://www.ebi.ac.uk/pdbsum/1oqn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqn ProSAT]</span></td></tr> |
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/DAB1_MOUSE DAB1_MOUSE] Adapter molecule functioning in neural development. May regulate SIAH1 activity.<ref>PMID:9009273</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
- | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqn_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqn_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
- | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqn ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
+ | <div class="pdbe-citations 1oqn" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
- | [[Category: Curran | + | [[Category: Rattus norvegicus]] |
- | [[Category: Dickerson | + | [[Category: Curran T]] |
- | [[Category: Keshvara | + | [[Category: Dickerson JB]] |
- | [[Category: Park | + | [[Category: Keshvara L]] |
- | [[Category: Park | + | [[Category: Park C-G]] |
- | [[Category: Rock | + | [[Category: Park H-W]] |
- | [[Category: Yun | + | [[Category: Rock CO]] |
- | [[Category: Zhang | + | [[Category: Yun M]] |
- | [[Category: Zheng | + | [[Category: Zhang Y-M]] |
- | + | [[Category: Zheng J]] | |
- | + | ||
- | + | ||
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Current revision
Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)
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Categories: Large Structures | Mus musculus | Rattus norvegicus | Curran T | Dickerson JB | Keshvara L | Park C-G | Park H-W | Rock CO | Yun M | Zhang Y-M | Zheng J