1xap

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:06, 25 October 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Structure of the ligand binding domain of the Retinoic Acid Receptor beta==
==Structure of the ligand binding domain of the Retinoic Acid Receptor beta==
-
<StructureSection load='1xap' size='340' side='right' caption='[[1xap]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+
<StructureSection load='1xap' size='340' side='right'caption='[[1xap]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1xap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XAP FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1xap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAP FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TTB:4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC+ACID'>TTB</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xap OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xap RCSB], [http://www.ebi.ac.uk/pdbsum/1xap PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTB:4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC+ACID'>TTB</scene></td></tr>
-
<table>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xap OCA], [https://pdbe.org/1xap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xap RCSB], [https://www.ebi.ac.uk/pdbsum/1xap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xap ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RARB_HUMAN RARB_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.<ref>PMID:12554770</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xap_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xap_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xap ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 24: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 1xap" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Retinoic acid receptor|Retinoic acid receptor]]
+
*[[Retinoic acid receptor 3D structures|Retinoic acid receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 32: Line 37:
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Daris, J P.]]
+
[[Category: Large Structures]]
-
[[Category: Germain, P.]]
+
[[Category: Daris JP]]
-
[[Category: Gronemeyer, H.]]
+
[[Category: De Lera AR]]
-
[[Category: Kammerer, S.]]
+
[[Category: Germain P]]
-
[[Category: Lapointe, P.]]
+
[[Category: Gronemeyer H]]
-
[[Category: Lera, A R.De.]]
+
[[Category: Kammerer S]]
-
[[Category: Marinier, A.]]
+
[[Category: Lapointe P]]
-
[[Category: Peluso-Iltis, C.]]
+
[[Category: Marinier A]]
-
[[Category: Rochel, N.]]
+
[[Category: Peluso-Iltis C]]
-
[[Category: Starrett, J.]]
+
[[Category: Rochel N]]
-
[[Category: Tortolani, D.]]
+
[[Category: Starrett J]]
-
[[Category: Zusi, F C.]]
+
[[Category: Tortolani D]]
-
[[Category: Ligand binding domain]]
+
[[Category: Zusi FC]]
-
[[Category: Nuclear receptor]]
+
-
[[Category: Retinoic acid receptor beta]]
+
-
[[Category: Transcription]]
+
-
[[Category: Ttnpb]]
+

Current revision

Structure of the ligand binding domain of the Retinoic Acid Receptor beta

PDB ID 1xap

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xap"
Personal tools