1fms

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[[Image:1fms.gif|left|200px]]
 
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{{Structure
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==Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)==
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|PDB= 1fms |SIZE=350|CAPTION= <scene name='initialview01'>1fms</scene>, resolution 1.9&Aring;
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<StructureSection load='1fms' size='340' side='right'caption='[[1fms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>
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<table><tr><td colspan='2'>[[1fms]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMS FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fms OCA], [https://pdbe.org/1fms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fms RCSB], [https://www.ebi.ac.uk/pdbsum/1fms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fms ProSAT]</span></td></tr>
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</table>
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'''Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Boykin DW]]
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
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[[Category: Kumar A]]
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[[Category: Lee M]]
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==About this Structure==
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[[Category: Neidle S]]
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1FMS is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA].
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[[Category: Simpson IJ]]
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==Reference==
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DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
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[[Category: Protein complex]]
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[[Category: Boykin, D W.]]
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[[Category: Kumar, A.]]
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[[Category: Lee, M.]]
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[[Category: Neidle, S.]]
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[[Category: Simpson, I J.]]
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[[Category: D35]]
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[[Category: MG]]
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[[Category: dna-drug minor groove complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:11:10 2008''
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Current revision

Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)

PDB ID 1fms

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