1fmq

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[[Image:1fmq.gif|left|200px]]
 
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{{Structure
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==Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG==
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|PDB= 1fmq |SIZE=350|CAPTION= <scene name='initialview01'>1fmq</scene>, resolution 2.&Aring;
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<StructureSection load='1fmq' size='340' side='right'caption='[[1fmq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>
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<table><tr><td colspan='2'>[[1fmq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D34:2,5-BIS{[4-(N-CYCLOBUTYLDIAMINOMETHYL)PHENYL]}FURAN'>D34</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmq OCA], [https://pdbe.org/1fmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fmq RCSB], [https://www.ebi.ac.uk/pdbsum/1fmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fmq ProSAT]</span></td></tr>
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</table>
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'''Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Boykin DW]]
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2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
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[[Category: Kumar A]]
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[[Category: Lee M]]
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==About this Structure==
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[[Category: Neidle S]]
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1FMQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMQ OCA].
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[[Category: Simpson IJ]]
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==Reference==
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DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11128631 11128631]
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[[Category: Protein complex]]
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[[Category: Boykin, D W.]]
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[[Category: Kumar, A.]]
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[[Category: Lee, M.]]
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[[Category: Neidle, S.]]
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[[Category: Simpson, I J.]]
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[[Category: D34]]
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[[Category: MG]]
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[[Category: dna-drug minor groove complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:11:16 2008''
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Current revision

Cyclo-butyl-bis-furamidine complexed with dCGCGAATTCGCG

PDB ID 1fmq

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