1sm8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:18, 23 August 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==M. tuberculosis dUTPase complexed with chromium and dUTP==
==M. tuberculosis dUTPase complexed with chromium and dUTP==
-
<StructureSection load='1sm8' size='340' side='right' caption='[[1sm8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+
<StructureSection load='1sm8' size='340' side='right'caption='[[1sm8]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1sm8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1SM8 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1sm8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SM8 FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR:CHROMIUM+ION'>CR</scene>, <scene name='pdbligand=DUT:DEOXYURIDINE-5-TRIPHOSPHATE'>DUT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mq7|1mq7]], [[1six|1six]], [[1sjn|1sjn]], [[1slh|1slh]], [[1smc|1smc]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CR:CHROMIUM+ION'>CR</scene>, <scene name='pdbligand=DUT:DEOXYURIDINE-5-TRIPHOSPHATE'>DUT</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sm8 OCA], [https://pdbe.org/1sm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sm8 RCSB], [https://www.ebi.ac.uk/pdbsum/1sm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sm8 ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dUTP_diphosphatase dUTP diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.23 3.6.1.23] </span></td></tr>
+
</table>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sm8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1sm8 RCSB], [http://www.ebi.ac.uk/pdbsum/1sm8 PDBsum]</span></td></tr>
+
== Function ==
-
<table>
+
[https://www.uniprot.org/uniprot/DUT_MYCTU DUT_MYCTU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.[HAMAP-Rule:MF_00116]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1sm8_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1sm8_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sm8 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 27: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 1sm8" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
-
*[[Deoxyuridine 5'-triphosphate nucleotidohydrolase|Deoxyuridine 5'-triphosphate nucleotidohydrolase]]
+
*[[DUTPase 3D structures|DUTPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
-
[[Category: DUTP diphosphatase]]
+
[[Category: Cascio D]]
-
[[Category: Cascio, D.]]
+
[[Category: Chan S]]
-
[[Category: Chan, S.]]
+
[[Category: Cho US]]
-
[[Category: Cho, U S.]]
+
[[Category: Eisenberg D]]
-
[[Category: Eisenberg, D.]]
+
[[Category: Kim C-Y]]
-
[[Category: Kim, C Y.]]
+
[[Category: Kim M-Y]]
-
[[Category: Kim, M Y.]]
+
[[Category: Krupka H]]
-
[[Category: Krupka, H.]]
+
[[Category: Lekin T]]
-
[[Category: Lekin, T.]]
+
[[Category: Naranjo CM]]
-
[[Category: Naranjo, C M.]]
+
[[Category: Park MS]]
-
[[Category: Park, M S.]]
+
[[Category: Pashkov I]]
-
[[Category: Pashkov, I.]]
+
[[Category: Perry JL]]
-
[[Category: Perry, J L.]]
+
[[Category: Rogers YC]]
-
[[Category: Rogers, Y C.]]
+
[[Category: Sawaya MR]]
-
[[Category: Sawaya, M R.]]
+
[[Category: Segelke B]]
-
[[Category: Segelke, B.]]
+
[[Category: So M]]
-
[[Category: So, M.]]
+
[[Category: Terwilliger TC]]
-
[[Category: TBSGC, TB Structural Genomics Consortium.]]
+
[[Category: Waldo GS]]
-
[[Category: Terwilliger, T C.]]
+
[[Category: Yeates TO]]
-
[[Category: Waldo, G S.]]
+
-
[[Category: Yeates, T O.]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Jelly-roll]]
+
-
[[Category: Protein structure initiative]]
+
-
[[Category: Psi]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Tb structural genomics consortium]]
+
-
[[Category: Tbsgc]]
+

Current revision

M. tuberculosis dUTPase complexed with chromium and dUTP

PDB ID 1sm8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sm8"
Personal tools