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2gw6

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==NMR structure of the human tRNA endonuclease SEN15 subunit==
==NMR structure of the human tRNA endonuclease SEN15 subunit==
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<StructureSection load='2gw6' size='340' side='right' caption='[[2gw6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2gw6' size='340' side='right'caption='[[2gw6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2gw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GW6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2gw6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GW6 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSEN15, C1orf19, SEN15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gw6 RCSB], [http://www.ebi.ac.uk/pdbsum/2gw6 PDBsum], [http://www.topsan.org/Proteins/CESG/2gw6 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gw6 OCA], [https://pdbe.org/2gw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gw6 RCSB], [https://www.ebi.ac.uk/pdbsum/2gw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gw6 ProSAT], [https://www.topsan.org/Proteins/CESG/2gw6 TOPSAN]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SEN15_HUMAN SEN15_HUMAN] Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3' end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3' end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.<ref>PMID:15109492</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2gw6" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Large Structures]]
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[[Category: Markley, J L.]]
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[[Category: Markley JL]]
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[[Category: Song, J.]]
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[[Category: Song J]]
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[[Category: Center for eukaryotic structural genomic]]
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[[Category: Cesg]]
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[[Category: Protein binding]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Sen15_human]]
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[[Category: Structural genomic]]
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[[Category: Trna endonuclease]]
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Current revision

NMR structure of the human tRNA endonuclease SEN15 subunit

PDB ID 2gw6

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