1fx3

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[[Image:1fx3.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF H. INFLUENZAE SECB==
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|PDB= 1fx3 |SIZE=350|CAPTION= <scene name='initialview01'>1fx3</scene>, resolution 2.50&Aring;
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<StructureSection load='1fx3' size='340' side='right'caption='[[1fx3]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1fx3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FX3 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fx3 OCA], [https://pdbe.org/1fx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fx3 RCSB], [https://www.ebi.ac.uk/pdbsum/1fx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fx3 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''CRYSTAL STRUCTURE OF H. INFLUENZAE SECB'''
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[https://www.uniprot.org/uniprot/SECB_HAEIN SECB_HAEIN] One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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SecB is a bacterial molecular chaperone involved in mediating translocation of newly synthesized polypeptides across the cytoplasmic membrane of bacteria. The crystal structure of SecB from Haemophilus influenzae shows that the molecule is a tetramer organized as a dimer of dimers. Two long channels run along the side of the molecule. These are bounded by flexible loops and lined with conserved hydrophobic amino acids, which define a suitable environment for binding non-native polypeptides. The structure also reveals an acidic region on the top surface of the molecule, several residues of which have been implicated in binding to SecA, its downstream target.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fx/1fx3_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1FX3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FX3 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fx3 ConSurf].
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Crystal structure of the bacterial protein export chaperone secB., Xu Z, Knafels JD, Yoshino K, Nat Struct Biol. 2000 Dec;7(12):1172-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101901 11101901]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Knafels, J D.]]
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[[Category: Knafels JD]]
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[[Category: Xu, Z.]]
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[[Category: Xu Z]]
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[[Category: Yoshino, K.]]
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[[Category: Yoshino K]]
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[[Category: protein trasnport]]
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[[Category: translocation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:15:10 2008''
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Current revision

CRYSTAL STRUCTURE OF H. INFLUENZAE SECB

PDB ID 1fx3

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