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2ad9
From Proteopedia
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==Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA== | ==Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA== | ||
| - | <StructureSection load='2ad9' size='340' side='right' caption='[[2ad9 | + | <StructureSection load='2ad9' size='340' side='right'caption='[[2ad9]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ad9]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ad9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AD9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AD9 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ad9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ad9 OCA], [https://pdbe.org/2ad9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ad9 RCSB], [https://www.ebi.ac.uk/pdbsum/2ad9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ad9 ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PTBP1_HUMAN PTBP1_HUMAN] Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:11003644</ref> <ref>PMID:15009664</ref> <ref>PMID:16260624</ref> <ref>PMID:21518792</ref> <ref>PMID:16179478</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad9_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2ad9_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ad9 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ad9" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Nucleoprotein|Nucleoprotein]] | + | *[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allain | + | [[Category: Large Structures]] |
| - | [[Category: Auweter | + | [[Category: Allain FHT]] |
| - | [[Category: Black | + | [[Category: Auweter SD]] |
| - | [[Category: Erat | + | [[Category: Black DL]] |
| - | [[Category: Hargous | + | [[Category: Erat M]] |
| - | [[Category: Henning | + | [[Category: Hargous Y]] |
| - | [[Category: Oberstrass | + | [[Category: Henning A]] |
| - | [[Category: Pitsch | + | [[Category: Oberstrass FC]] |
| - | [[Category: Reymond | + | [[Category: Pitsch S]] |
| - | [[Category: Wenter | + | [[Category: Reymond L]] |
| - | + | [[Category: Wenter P]] | |
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Current revision
Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA
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Categories: Homo sapiens | Large Structures | Allain FHT | Auweter SD | Black DL | Erat M | Hargous Y | Henning A | Oberstrass FC | Pitsch S | Reymond L | Wenter P
