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2exe
From Proteopedia
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==Crystal structure of the phosphorylated CLK3== | ==Crystal structure of the phosphorylated CLK3== | ||
| - | <StructureSection load='2exe' size='340' side='right' caption='[[2exe]], [[Resolution|resolution]] 2.35Å' scene=''> | + | <StructureSection load='2exe' size='340' side='right'caption='[[2exe]], [[Resolution|resolution]] 2.35Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2exe]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2exe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EXE FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2exe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2exe OCA], [https://pdbe.org/2exe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2exe RCSB], [https://www.ebi.ac.uk/pdbsum/2exe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2exe ProSAT]</span></td></tr> | |
| - | <tr | + | </table> |
| - | + | == Function == | |
| - | <table> | + | [https://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exe_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/2exe_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2exe ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | [[Category: Ball | + | [[Category: Ball LJ]] |
| - | [[Category: Bullock | + | [[Category: Bullock A]] |
| - | [[Category: Das | + | [[Category: Das S]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Fedorov O]] |
| - | [[Category: Fedorov | + | [[Category: Johansson C]] |
| - | [[Category: Johansson | + | [[Category: Knapp S]] |
| - | [[Category: Knapp | + | [[Category: Papagrigoriou E]] |
| - | [[Category: Papagrigoriou | + | [[Category: Rellos P]] |
| - | [[Category: Rellos | + | [[Category: Savitsky P]] |
| - | + | [[Category: Sobott F]] | |
| - | [[Category: Savitsky | + | [[Category: Sundstrom M]] |
| - | [[Category: Sobott | + | [[Category: Turnbull A]] |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Ugochukwu | + | [[Category: Von Delft F]] |
| - | [[Category: Weigelt | + | |
| - | [[Category: | + | |
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Current revision
Crystal structure of the phosphorylated CLK3
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Ball LJ | Bullock A | Das S | Edwards A | Fedorov O | Johansson C | Knapp S | Papagrigoriou E | Rellos P | Savitsky P | Sobott F | Sundstrom M | Turnbull A | Ugochukwu E | Weigelt J | Von Delft F
