2nbt
From Proteopedia
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==NEURONAL BUNGAROTOXIN, NMR, 10 STRUCTURES== | ==NEURONAL BUNGAROTOXIN, NMR, 10 STRUCTURES== | ||
| - | <StructureSection load='2nbt' size='340' side='right' caption='[[2nbt]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='2nbt' size='340' side='right'caption='[[2nbt]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2nbt]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2nbt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_multicinctus Bungarus multicinctus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nbt 1nbt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NBT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NBT FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nbt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nbt OCA], [https://pdbe.org/2nbt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nbt RCSB], [https://www.ebi.ac.uk/pdbsum/2nbt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nbt ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NXL1_BUNMU NXL1_BUNMU]] Neurotoxin. Binds and inhibits nicotinic acetylcholine receptors. Compared to alpha-neurotoxins, kappa-neurotoxins bind more strongly to neuronal receptors, and less strongly to muscle receptors.<ref>PMID:3986193</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/2nbt_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/2nbt_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2nbt ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2nbt" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Bungarotoxin|Bungarotoxin]] | + | *[[Bungarotoxin 3D structures|Bungarotoxin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bungarus multicinctus]] | [[Category: Bungarus multicinctus]] | ||
| - | [[Category: Bamberger, M | + | [[Category: Large Structures]] |
| - | [[Category: Braswell, E | + | [[Category: Bamberger, M]] |
| - | [[Category: Dobson, C M | + | [[Category: Braswell, E]] |
| - | [[Category: Loring, R H | + | [[Category: Dobson, C M]] |
| - | [[Category: Oswald, R E | + | [[Category: Loring, R H]] |
| - | [[Category: Sutcliffe, M J | + | [[Category: Oswald, R E]] |
| + | [[Category: Sutcliffe, M J]] | ||
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
[[Category: Venom]] | [[Category: Venom]] | ||
Current revision
NEURONAL BUNGAROTOXIN, NMR, 10 STRUCTURES
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