2a4g

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==Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound==
==Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound==
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<StructureSection load='2a4g' size='340' side='right' caption='[[2a4g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2a4g' size='340' side='right'caption='[[2a4g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2a4g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2a4g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_hominis Hepacivirus hominis] and [https://en.wikipedia.org/wiki/Hepatitis_C_virus_subtype_1b Hepatitis C virus subtype 1b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4G FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNH:({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC+ACID+ISOBUTYL+ESTER'>UNH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4g RCSB], [http://www.ebi.ac.uk/pdbsum/2a4g PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNH:({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC+ACID+ISOBUTYL+ESTER'>UNH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<table>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4g OCA], [https://pdbe.org/2a4g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4g RCSB], [https://www.ebi.ac.uk/pdbsum/2a4g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9QP61_9HEPC Q9QP61_9HEPC]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2a4g" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Helicase|Helicase]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hepatitis c virus]]
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[[Category: Hepacivirus hominis]]
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[[Category: Arasappan, A.]]
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[[Category: Hepatitis C virus subtype 1b]]
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[[Category: Bennett, F.]]
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[[Category: Large Structures]]
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[[Category: Bogen, S L.]]
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[[Category: Arasappan A]]
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[[Category: Butkiewicz, N.]]
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[[Category: Bennett F]]
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[[Category: Chan, T Y.]]
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[[Category: Bogen SL]]
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[[Category: Chen, K.]]
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[[Category: Butkiewicz N]]
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[[Category: Ganguly, A K.]]
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[[Category: Chan TY]]
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[[Category: Girijavallabhan, V.]]
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[[Category: Chen K]]
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[[Category: Gu, H.]]
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[[Category: Ganguly AK]]
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[[Category: Hong, L.]]
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[[Category: Girijavallabhan V]]
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[[Category: Ingram, R.]]
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[[Category: Gu H]]
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[[Category: Jao, E.]]
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[[Category: Hong L]]
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[[Category: Kemp, S.]]
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[[Category: Ingram R]]
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[[Category: Levy, O.]]
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[[Category: Jao E]]
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[[Category: Lim-Wilby, M.]]
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[[Category: Kemp S]]
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[[Category: Liu, Y T.]]
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[[Category: Levy O]]
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[[Category: Lovey, R G.]]
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[[Category: Lim-Wilby M]]
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[[Category: Malcolm, B.]]
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[[Category: Liu YT]]
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[[Category: Marten, B.]]
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[[Category: Lovey RG]]
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[[Category: Mckittrick, B.]]
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[[Category: Madison V]]
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[[Category: Njoroge, F G.]]
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[[Category: Malcolm B]]
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[[Category: Parekh, T.]]
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[[Category: Marten B]]
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[[Category: Pichardo, J.]]
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[[Category: Mckittrick B]]
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[[Category: Pike, R E.]]
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[[Category: Njoroge FG]]
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[[Category: Pinto, P.]]
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[[Category: Parekh T]]
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[[Category: Prongay, A J.]]
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[[Category: Pichardo J]]
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[[Category: Saksena, A K.]]
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[[Category: Pike RE]]
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[[Category: Santhanam, B.]]
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[[Category: Pinto P]]
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[[Category: Tamura, S.]]
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[[Category: Prongay AJ]]
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[[Category: V., Madison]]
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[[Category: Saksena AK]]
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[[Category: Vaccaro, H.]]
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[[Category: Santhanam B]]
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[[Category: Venkatraman, S.]]
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[[Category: Tamura S]]
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[[Category: Wang, H.]]
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[[Category: Vaccaro H]]
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[[Category: Yang, X.]]
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[[Category: Venkatraman S]]
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[[Category: Yao, N.]]
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[[Category: Wang H]]
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[[Category: Zhu, Z.]]
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[[Category: Yang X]]
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[[Category: Viral protein]]
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[[Category: Yao N]]
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[[Category: Zhu Z]]

Current revision

Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound

PDB ID 2a4g

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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