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2l0t
From Proteopedia
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==Solution structure of the complex of ubiquitin and the VHS domain of Stam2== | ==Solution structure of the complex of ubiquitin and the VHS domain of Stam2== | ||
| - | <StructureSection load='2l0t' size='340' side='right' caption='[[2l0t | + | <StructureSection load='2l0t' size='340' side='right'caption='[[2l0t]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l0t]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0T FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0t OCA], [https://pdbe.org/2l0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0t RCSB], [https://www.ebi.ac.uk/pdbsum/2l0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0t ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). | |
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==See Also== | ==See Also== | ||
| - | *[[ | + | *[[3D structures of ubiquitin|3D structures of ubiquitin]] |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hoeller | + | [[Category: Large Structures]] |
| - | [[Category: Lancelin | + | [[Category: Hoeller D]] |
| - | [[Category: Lange | + | [[Category: Lancelin J]] |
| - | [[Category: Marcillat | + | [[Category: Lange A]] |
| - | [[Category: Walker | + | [[Category: Marcillat O]] |
| - | [[Category: Wienk | + | [[Category: Walker O]] |
| - | + | [[Category: Wienk H]] | |
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Current revision
Solution structure of the complex of ubiquitin and the VHS domain of Stam2
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Categories: Homo sapiens | Large Structures | Hoeller D | Lancelin J | Lange A | Marcillat O | Walker O | Wienk H
