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1g2b

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[[Image:1g2b.jpg|left|200px]]
 
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{{Structure
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==ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48==
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|PDB= 1g2b |SIZE=350|CAPTION= <scene name='initialview01'>1g2b</scene>, resolution 1.12&Aring;
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<StructureSection load='1g2b' size='340' side='right'caption='[[1g2b]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1g2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G2B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.12&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2b OCA], [https://pdbe.org/1g2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g2b RCSB], [https://www.ebi.ac.uk/pdbsum/1g2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2b ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/1g2b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g2b ConSurf].
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<div style="clear:both"></div>
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'''ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48'''
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==See Also==
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The crystal structure of an alpha-spectrin Src-homology 3 (SH3) domain mutant has been refined at 1.12 A resolution. This X-ray structure is at the highest resolution achieved so far for an SH3 domain. The structure allows the identification of a complete set of specific interactions and is useful for the elucidation of relations between structure and pH-dependent thermodynamic stability in a series of SH3 domain mutants.
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==About this Structure==
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1G2B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2B OCA].
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==Reference==
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Atomic resolution structure of a mutant of the spectrin SH3 domain., Berisio R, Viguera A, Serrano L, Wilmanns M, Acta Crystallogr D Biol Crystallogr. 2001 Feb;57(Pt 2):337-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11173498 11173498]
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Berisio, R.]]
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[[Category: Berisio R]]
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[[Category: Serrano, L.]]
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[[Category: Serrano L]]
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[[Category: Viguera, A R.]]
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[[Category: Viguera AR]]
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[[Category: Wilmanns, M.]]
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[[Category: Wilmanns M]]
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[[Category: SO4]]
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[[Category: calcium-binding]]
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[[Category: capping protein]]
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[[Category: cytoskeleton]]
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[[Category: duplication]]
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[[Category: repeat]]
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[[Category: sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:17:13 2008''
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Current revision

ALPHA-SPECTRIN SRC HOMOLOGY 3 DOMAIN, CIRCULAR PERMUTANT, CUT AT N47-D48

PDB ID 1g2b

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