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2o2v
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==Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)== | ==Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)== | ||
| - | <StructureSection load='2o2v' size='340' side='right' caption='[[2o2v]], [[Resolution|resolution]] 1.83Å' scene=''> | + | <StructureSection load='2o2v' size='340' side='right'caption='[[2o2v]], [[Resolution|resolution]] 1.83Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2o2v]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2o2v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O2V FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o2v OCA], [https://pdbe.org/2o2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o2v RCSB], [https://www.ebi.ac.uk/pdbsum/2o2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o2v ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MP2K5_HUMAN MP2K5_HUMAN] Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.<ref>PMID:7759517</ref> <ref>PMID:9384584</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Mitogen-activated protein kinase kinase|Mitogen-activated protein kinase kinase]] | + | *[[Mitogen-activated protein kinase kinase 3D structures|Mitogen-activated protein kinase kinase 3D structures]] |
*[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | *[[Mitogen-activated protein kinase kinase kinase|Mitogen-activated protein kinase kinase kinase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith C]] |
| - | + | [[Category: Edwards A]] | |
| - | [[Category: Edwards | + | [[Category: Filippakopoulos P]] |
| - | [[Category: Filippakopoulos | + | [[Category: Knapp S]] |
| - | [[Category: Knapp | + | [[Category: Savitsky P]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Savitsky | + | [[Category: Ugochukwu E]] |
| - | [[Category: Sundstrom | + | [[Category: Von Delft F]] |
| - | [[Category: Ugochukwu | + | |
| - | [[Category: | + | |
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Current revision
Crystal Structure of the Complex of Human Mitogen Activated Protein Kinase Kinase 5 Phox Domain (MAP2K5-phox) with Human Mitogen Activated Protein Kinase Kinase Kinase 3 (MAP3K3B-phox)
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