1g2t

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[[Image:1g2t.jpg|left|200px]]
 
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{{Structure
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==SOLUTION STRUCTURE OF EOTAXIN-3==
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|PDB= 1g2t |SIZE=350|CAPTION= <scene name='initialview01'>1g2t</scene>
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<StructureSection load='1g2t' size='340' side='right'caption='[[1g2t]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1g2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G2T FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= EOTAXIN-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2t OCA], [https://pdbe.org/1g2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g2t RCSB], [https://www.ebi.ac.uk/pdbsum/1g2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2t ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''SOLUTION STRUCTURE OF EOTAXIN-3'''
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[https://www.uniprot.org/uniprot/CCL26_HUMAN CCL26_HUMAN] Chemotactic for eosinophils and basophils. Binds to CCR3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Eotaxin-3 is one of three related chemokines that specifically activate chemokine receptor CCR3. We report the 3D structure and backbone dynamics of eotaxin-3 determined by NMR spectroscopy. Eotaxin-3 is monomeric under the conditions in this study and consists of an unstructured N-terminus before the first two conserved cysteine residues, an irregularly structured N-loop following the second conserved cysteine, a single turn of 3(10)-helix, a three-stranded antiparallel beta-sheet, an alpha-helix, and an unstructured C-terminal tail. As in other chemokines, the alpha-helix packs against one face of the beta-sheet. The average backbone and heavy atom rmsd values of the 20 structures (residues 9-65) are 0.44 and 1.01 A, respectively. A comparison between the structures of eotaxin-3 and related chemokines suggests that the electrostatic potential in the vicinity of a surface groove and the structure of the beta2-beta3 turn may be important for maintaining receptor specificity. The backbone dynamics of eotaxin-3 were determined from 15N NMR relaxation data using the extended model free dynamics formalism. Large amplitude motions on the picosecond to nanosecond time scale were observed in both termini and in some residues in the N-loop, the beta1-beta2 turn, and the beta3 strand; the location of these residues suggests a possible role for dynamics in receptor binding and activation. In contrast to eotaxin, eotaxin-3 exhibits no substantial mobility on the microsecond to millisecond time scale.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g2/1g2t_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1G2T is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2T OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g2t ConSurf].
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NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3., Ye J, Mayer KL, Mayer MR, Stone MJ, Biochemistry. 2001 Jul 3;40(26):7820-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11425309 11425309]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Mayer, K L.]]
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[[Category: Mayer KL]]
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[[Category: Mayer, M R.]]
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[[Category: Mayer MR]]
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[[Category: Stone, M J.]]
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[[Category: Stone MJ]]
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[[Category: Ye, J.]]
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[[Category: Ye J]]
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[[Category: beta-beta-beta-alpha helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:17:24 2008''
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Current revision

SOLUTION STRUCTURE OF EOTAXIN-3

PDB ID 1g2t

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