2ljb
From Proteopedia
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==Structure of the influenza AM2-BM2 chimeric channel== | ==Structure of the influenza AM2-BM2 chimeric channel== | ||
| - | <StructureSection load='2ljb' size='340' side='right' caption='[[2ljb | + | <StructureSection load='2ljb' size='340' side='right'caption='[[2ljb]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ljb]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ljb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_H3N2 Influenza A virus H3N2] and [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Taiwan/70061/2006) Influenza B virus (B/Taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJB FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljb OCA], [https://pdbe.org/2ljb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljb RCSB], [https://www.ebi.ac.uk/pdbsum/2ljb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljb ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/B4UQM4_9INFB B4UQM4_9INFB] [https://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ljb" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Influenza A virus H3N2]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chou JJ]] |
| - | [[Category: | + | [[Category: Oxenoid K]] |
| - | [[Category: | + | [[Category: Pielak RM]] |
Current revision
Structure of the influenza AM2-BM2 chimeric channel
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