2ix2

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==CRYSTAL STRUCTURE OF THE HETEROTRIMERIC PCNA FROM SULFOLOBUS SOLFATARICUS==
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<StructureSection load='2ix2' size='340' side='right' caption='[[2ix2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==Crystal structure of the heterotrimeric PCNA from Sulfolobus solfataricus==
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<StructureSection load='2ix2' size='340' side='right'caption='[[2ix2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ix2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IX2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ix2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IX2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2izo|2izo]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ix2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ix2 RCSB], [http://www.ebi.ac.uk/pdbsum/2ix2 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ix2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix2 OCA], [https://pdbe.org/2ix2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ix2 RCSB], [https://www.ebi.ac.uk/pdbsum/2ix2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ix2 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCNA1_SACS2 PCNA1_SACS2] One of the sliding clamp subunits that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. Heterotrimer stimulates the Holliday junction resolvase Hjc. DNA polymerase I, DNA ligase and the flap endonuclease may be constitutively associated with the PCNA heterotrimer forming a scanning complex able to couple DNA synthesis and Okazaki fragment maturation.<ref>PMID:12535540</ref> <ref>PMID:17011573</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ix2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/2ix2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ix2 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ix2" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Proliferating Cell Nuclear Antigen|Proliferating Cell Nuclear Antigen]]
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*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sulfolobus solfataricus]]
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[[Category: Large Structures]]
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[[Category: Carter, L.]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Johnson, K.]]
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[[Category: Carter L]]
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[[Category: Liu, H.]]
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[[Category: Johnson K]]
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[[Category: Mcmahon, S A.]]
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[[Category: Liu H]]
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[[Category: Naismith, J H.]]
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[[Category: McMahon SA]]
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[[Category: Oke, M.]]
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[[Category: Naismith JH]]
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[[Category: Taylor, G L.]]
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[[Category: Oke M]]
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[[Category: White, M F.]]
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[[Category: Taylor GL]]
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[[Category: Williams, G J.]]
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[[Category: White MF]]
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[[Category: Dna replication]]
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[[Category: Williams GJ]]
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[[Category: Dna-binding]]
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[[Category: Pcna]]
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[[Category: Replication]]
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[[Category: Sulfolobus sulfataricus]]
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Current revision

Crystal structure of the heterotrimeric PCNA from Sulfolobus solfataricus

PDB ID 2ix2

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