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2l73
From Proteopedia
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==Structure of the NOXO1b PX domain== | ==Structure of the NOXO1b PX domain== | ||
| - | <StructureSection load='2l73' size='340' side='right' caption='[[2l73 | + | <StructureSection load='2l73' size='340' side='right'caption='[[2l73]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l73]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L73 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <table> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l73 OCA], [https://pdbe.org/2l73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l73 RCSB], [https://www.ebi.ac.uk/pdbsum/2l73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l73 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NOXO1_HUMAN NOXO1_HUMAN] Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.<ref>PMID:12657628</ref> <ref>PMID:14617635</ref> <ref>PMID:15949904</ref> <ref>PMID:15326186</ref> <ref>PMID:15824103</ref> <ref>PMID:16329988</ref> <ref>PMID:17126813</ref> <ref>PMID:19755710</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Davis NY]] |
| - | [[Category: | + | [[Category: Horita DA]] |
| - | [[Category: | + | [[Category: McPhail LC]] |
| - | + | ||
| - | + | ||
Current revision
Structure of the NOXO1b PX domain
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