2cw0

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==Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution==
==Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution==
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<StructureSection load='2cw0' size='340' side='right' caption='[[2cw0]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='2cw0' size='340' side='right'caption='[[2cw0]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2cw0]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CW0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2cw0]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus], [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27] and [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CW0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cw0 RCSB], [http://www.ebi.ac.uk/pdbsum/2cw0 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cw0 OCA], [https://pdbe.org/2cw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cw0 RCSB], [https://www.ebi.ac.uk/pdbsum/2cw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cw0 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPOA_THET8 RPOA_THET8] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw0_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/2cw0_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cw0 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2cw0" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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*[[Sigma factor 3D structures|Sigma factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Arnold, E.]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Birktoft, J J.]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Borukhov, S.]]
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[[Category: Arnold E]]
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[[Category: Clark, A D.]]
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[[Category: Birktoft JJ]]
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[[Category: Dharia, C.]]
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[[Category: Borukhov S]]
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[[Category: Ebright, R H.]]
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[[Category: Clark Jr AD]]
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[[Category: Hudson, B.]]
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[[Category: Dharia C]]
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[[Category: Ismail, S.]]
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[[Category: Ebright RH]]
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[[Category: Laptenko, O.]]
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[[Category: Hudson B]]
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[[Category: Lee, J.]]
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[[Category: Ismail S]]
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[[Category: Leroy, O.]]
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[[Category: Laptenko O]]
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[[Category: Mukhopadhyay, J.]]
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[[Category: Lee J]]
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[[Category: Napoli, A.]]
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[[Category: Leroy O]]
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[[Category: Sarafianos, S G.]]
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[[Category: Mukhopadhyay J]]
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[[Category: Sineva, E.]]
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[[Category: Napoli A]]
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[[Category: Tuske, S.]]
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[[Category: Sarafianos SG]]
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[[Category: Wang, X.]]
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[[Category: Sineva E]]
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[[Category: Bent-bridge helix]]
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[[Category: Tuske S]]
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[[Category: Rna polymerase holoenzyme]]
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[[Category: Wang X]]
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[[Category: Transcription]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution

PDB ID 2cw0

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