2zlf

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==The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase==
==The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase==
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<StructureSection load='2zlf' size='340' side='right' caption='[[2zlf]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
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<StructureSection load='2zlf' size='340' side='right'caption='[[2zlf]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2zlf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZLF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2zlf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZLF FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zlg|2zlg]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zlf OCA], [https://pdbe.org/2zlf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zlf RCSB], [https://www.ebi.ac.uk/pdbsum/2zlf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zlf ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zlf RCSB], [http://www.ebi.ac.uk/pdbsum/2zlf PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/RIR1_YEAST RIR1_YEAST] Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.<ref>PMID:11893751</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zl/2zlf_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zl/2zlf_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zlf ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2zlf" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Ribonucleotide reductase|Ribonucleotide reductase]]
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*[[Ribonucleotide reductase 3D structures|Ribonucleotide reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ribonucleoside-diphosphate reductase]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Cooperman, B S.]]
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[[Category: Cooperman BS]]
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[[Category: Dealwis, C.]]
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[[Category: Dealwis C]]
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[[Category: Fairman, J W.]]
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[[Category: Fairman JW]]
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[[Category: Helmbrecht, E.]]
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[[Category: Helmbrecht E]]
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[[Category: Kreischer, N R.]]
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[[Category: Kreischer NR]]
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[[Category: LaMacchia, J.]]
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[[Category: LaMacchia J]]
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[[Category: Wijerathna, S R.]]
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[[Category: Wijerathna SR]]
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[[Category: Xu, H.]]
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[[Category: Xu H]]
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[[Category: Allosteric enzyme]]
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[[Category: Atp-binding]]
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[[Category: Dna replication]]
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[[Category: Nucleotide-binding]]
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[[Category: Oxidoreductase]]
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[[Category: Peptidomimetic inhibition eukaryotic ribonucleotide reductase]]
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[[Category: Phosphoprotein]]
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Current revision

The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase

PDB ID 2zlf

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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