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2vcx

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==COMPLEX STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE AT 2.1A.==
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<StructureSection load='2vcx' size='340' side='right' caption='[[2vcx]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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==Complex structure of prostaglandin D2 synthase at 2.1A.==
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<StructureSection load='2vcx' size='340' side='right'caption='[[2vcx]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vcx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VCX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v40|1v40]], [[2vcq|2vcq]], [[2vcw|2vcw]], [[1iyh|1iyh]], [[1iyi|1iyi]], [[2vcz|2vcz]], [[2vd0|2vd0]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D26:PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE'>D26</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-D_synthase Prostaglandin-D synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.2 5.3.99.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [https://pdbe.org/2vcx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [https://www.ebi.ac.uk/pdbsum/2vcx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vcx ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vcx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vcx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vcx RCSB], [http://www.ebi.ac.uk/pdbsum/2vcx PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcx_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vc/2vcx_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vcx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2vcx" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Glutathione S-transferase|Glutathione S-transferase]]
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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*[[Prostaglandin D synthase|Prostaglandin D synthase]]
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Prostaglandin-D synthase]]
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[[Category: Large Structures]]
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[[Category: Dahmen, J.]]
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[[Category: Dahmen J]]
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[[Category: Edman, K.]]
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[[Category: Edman K]]
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[[Category: Folmer, R H.A.]]
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[[Category: Folmer RHA]]
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[[Category: Groth-Clausen, I.]]
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[[Category: Groth-Clausen I]]
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[[Category: Hawtin, P.]]
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[[Category: Hawtin P]]
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[[Category: Hohwy, M.]]
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[[Category: Hohwy M]]
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[[Category: Lundquist, B.]]
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[[Category: Lundquist B]]
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[[Category: Persdotter, S.]]
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[[Category: Persdotter S]]
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[[Category: Spadola, L.]]
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[[Category: Spadola L]]
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[[Category: Wachenfeldt, K Von.]]
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[[Category: Von Wachenfeldt K]]
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[[Category: Asthma]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Isomerase]]
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[[Category: Lipid synthesis]]
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[[Category: Pgd]]
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[[Category: Prostaglandin biosynthesis]]
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[[Category: Prostaglandin d2 synthase]]
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Current revision

Complex structure of prostaglandin D2 synthase at 2.1A.

PDB ID 2vcx

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