2wjx
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | == | + | |
| - | <StructureSection load='2wjx' size='340' side='right' caption='[[2wjx]], [[Resolution|resolution]] 4.10Å' scene=''> | + | ==Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution== |
| + | <StructureSection load='2wjx' size='340' side='right'caption='[[2wjx]], [[Resolution|resolution]] 4.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wjx]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wjx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WJX FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wjw|2wjw]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wjw|2wjw]]</div></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wjx OCA], [https://pdbe.org/2wjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wjx RCSB], [https://www.ebi.ac.uk/pdbsum/2wjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wjx ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/GRIA2_HUMAN GRIA2_HUMAN]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:20614889</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wjx_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/2wjx_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wjx ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
| Line 24: | Line 27: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2wjx" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Aricescu, A R | + | [[Category: Large Structures]] |
| - | [[Category: Clayton, A | + | [[Category: Aricescu, A R]] |
| - | [[Category: Gilbert, R J.C | + | [[Category: Clayton, A]] |
| - | [[Category: Harlos, K | + | [[Category: Gilbert, R J.C]] |
| - | [[Category: Jones, E Y | + | [[Category: Harlos, K]] |
| - | [[Category: | + | [[Category: Jones, E Y]] |
| - | [[Category: Siebold, C | + | [[Category: McIlhinney, R A.J]] |
| - | [[Category: Sutton, G C | + | [[Category: Siebold, C]] |
| + | [[Category: Sutton, G C]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Cell junction]] | [[Category: Cell junction]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
| Line 52: | Line 58: | ||
[[Category: Palmitate]] | [[Category: Palmitate]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Postsynaptic cell membrane]] | [[Category: Postsynaptic cell membrane]] | ||
[[Category: Receptor]] | [[Category: Receptor]] | ||
Current revision
Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution
| |||||||||||
Categories: Human | Large Structures | Aricescu, A R | Clayton, A | Gilbert, R J.C | Harlos, K | Jones, E Y | McIlhinney, R A.J | Siebold, C | Sutton, G C | Alternative splicing | Cell junction | Cell membrane | Glur2 | Glutamate receptor | Glycoprotein | Ion channel | Ion transport | Ionic channel | Lipoprotein | Membrane | Palmitate | Phosphoprotein | Polymorphism | Postsynaptic cell membrane | Receptor | Rna editing | Synapse | Synaptic plasticity | Transmembrane | Transport | Transport protein
