This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2v00

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:59, 13 December 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
==X-RAY CRYSTAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH COMPOUND 1==
+
 
-
<StructureSection load='2v00' size='340' side='right' caption='[[2v00]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+
==X-ray crystal structure of endothiapepsin complexed with compound 1==
 +
<StructureSection load='2v00' size='340' side='right'caption='[[2v00]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2v00]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V00 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2v00]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V00 FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=V15:2-AMINO-6-(2-PHENYLETHYL)PYRIMIDIN-4(3H)-ONE'>V15</scene><br>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e5o|1e5o]], [[1e80|1e80]], [[1e81|1e81]], [[1e82|1e82]], [[1eed|1eed]], [[1ent|1ent]], [[1gkt|1gkt]], [[1gvt|1gvt]], [[1gvu|1gvu]], [[1gvv|1gvv]], [[1gvw|1gvw]], [[1gvx|1gvx]], [[1od1|1od1]], [[1oew|1oew]], [[1oex|1oex]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=V15:2-AMINO-6-(2-PHENYLETHYL)PYRIMIDIN-4(3H)-ONE'>V15</scene></td></tr>
-
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v00 OCA], [https://pdbe.org/2v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v00 RCSB], [https://www.ebi.ac.uk/pdbsum/2v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v00 ProSAT]</span></td></tr>
-
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v00 RCSB], [http://www.ebi.ac.uk/pdbsum/2v00 PDBsum]</span></td></tr>
+
</table>
-
<table>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v00_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v00_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
-
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v00 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
Line 26: Line 28:
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
 +
<div class="pdbe-citations 2v00" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
Line 34: Line 37:
</StructureSection>
</StructureSection>
[[Category: Cryphonectria parasitica]]
[[Category: Cryphonectria parasitica]]
-
[[Category: Endothiapepsin]]
+
[[Category: Large Structures]]
-
[[Category: Albert, J S.]]
+
[[Category: Albert JS]]
-
[[Category: Beer, T De.]]
+
[[Category: De Beer T]]
-
[[Category: Deinum, J.]]
+
[[Category: Deinum J]]
-
[[Category: Edwards, P D.]]
+
[[Category: Edwards PD]]
-
[[Category: Folmer, R H.A.]]
+
[[Category: Folmer RHA]]
-
[[Category: Geschwindner, S.]]
+
[[Category: Geschwindner S]]
-
[[Category: Olsson, L L.]]
+
[[Category: Olsson LL]]
-
[[Category: Alzheimer's disease]]
+
-
[[Category: Aspartyl protease]]
+
-
[[Category: B- secretase]]
+
-
[[Category: Bace]]
+
-
[[Category: Endothiapepsin]]
+
-
[[Category: Fragment hit]]
+
-
[[Category: Fragment-based lead generation]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Isocytosine]]
+
-
[[Category: Protease]]
+
-
[[Category: Surrogate protein]]
+
-
[[Category: Zymogen]]
+

Current revision

X-ray crystal structure of endothiapepsin complexed with compound 1

PDB ID 2v00

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2v00"
Personal tools