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3bg4

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==The crystal structure of guamerin in complex with chymotrypsin and the development of an elastase-specific inhibitor==
==The crystal structure of guamerin in complex with chymotrypsin and the development of an elastase-specific inhibitor==
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<StructureSection load='3bg4' size='340' side='right' caption='[[3bg4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3bg4' size='340' side='right'caption='[[3bg4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bg4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Hirudo_nipponia Hirudo nipponia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BG4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bg4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Hirudo_nipponia Hirudo nipponia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BG4 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chymotrypsin Chymotrypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.1 3.4.21.1] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bg4 RCSB], [http://www.ebi.ac.uk/pdbsum/3bg4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bg4 OCA], [https://pdbe.org/3bg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bg4 RCSB], [https://www.ebi.ac.uk/pdbsum/3bg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bg4 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTRB_BOVIN CTRB_BOVIN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bg4_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bg4_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bg4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3bg4" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Chymotrypsin|Chymotrypsin]]
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*[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Chymotrypsin]]
 
[[Category: Hirudo nipponia]]
[[Category: Hirudo nipponia]]
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[[Category: Choi, J.]]
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[[Category: Large Structures]]
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[[Category: Chu, T T.T.]]
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[[Category: Choi J]]
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[[Category: Hahn, M J.]]
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[[Category: Chu TTT]]
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[[Category: Kim, D R.]]
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[[Category: Hahn MJ]]
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[[Category: Kim, D Y.]]
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[[Category: Kim DR]]
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[[Category: Kim, H.]]
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[[Category: Kim DY]]
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[[Category: Kim, K K.]]
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[[Category: Kim H]]
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[[Category: Lee, J R.]]
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[[Category: Kim KK]]
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[[Category: Nguyen, C M.T.]]
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[[Category: Lee JR]]
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[[Category: Chymotrypsin]]
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[[Category: Nguyen CMT]]
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[[Category: Digestion]]
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[[Category: Elastase]]
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[[Category: Guamerin]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor]]
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[[Category: Protease]]
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[[Category: Protease inhibitor]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Serine protease inhibitor]]
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[[Category: Zymogen]]
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Current revision

The crystal structure of guamerin in complex with chymotrypsin and the development of an elastase-specific inhibitor

PDB ID 3bg4

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