2uxs

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==2.7A CRYSTAL STRUCTURE OF INORGANIC PYROPHOSPHATASE (RV3628) FROM MYCOBACTERIUM TUBERCULOSIS AT PH 7.5==
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<StructureSection load='2uxs' size='340' side='right' caption='[[2uxs]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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==2.7A crystal structure of inorganic pyrophosphatase (Rv3628) from Mycobacterium tuberculosis at pH 7.5==
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<StructureSection load='2uxs' size='340' side='right'caption='[[2uxs]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2uxs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2UXS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2uxs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UXS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UXS FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sxv|1sxv]], [[1wcf|1wcf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uxs OCA], [https://pdbe.org/2uxs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uxs RCSB], [https://www.ebi.ac.uk/pdbsum/2uxs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uxs ProSAT], [https://www.topsan.org/Proteins/RSGI/2uxs TOPSAN]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2uxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2uxs RCSB], [http://www.ebi.ac.uk/pdbsum/2uxs PDBsum], [http://www.topsan.org/Proteins/RSGI/2uxs TOPSAN]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/IPYR_MYCTU IPYR_MYCTU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ux/2uxs_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ux/2uxs_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uxs ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Inorganic pyrophosphatase|Inorganic pyrophosphatase]]
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*[[Inorganic pyrophosphatase 3D structures|Inorganic pyrophosphatase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Inorganic diphosphatase]]
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[[Category: Large Structures]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Cianci, M.]]
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[[Category: Cianci M]]
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[[Category: Cole, R E.]]
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[[Category: Cole RE]]
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[[Category: Hall, J F.]]
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[[Category: Hall JF]]
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[[Category: Hasnain, S S.]]
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[[Category: Hasnain SS]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Matsuda, T.]]
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[[Category: Matsuda T]]
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[[Category: Tabernero, L.]]
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[[Category: Tabernero L]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Hydrolase]]
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[[Category: Inorganic pyrophosphatase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Ppase]]
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[[Category: Rv3628]]
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Current revision

2.7A crystal structure of inorganic pyrophosphatase (Rv3628) from Mycobacterium tuberculosis at pH 7.5

PDB ID 2uxs

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