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2v2e

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==STRUCTURE OF ISONIAZID (INH) BOUND TO CYTOCHROME C PEROXIDASE MUTANT N184R Y36A==
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<StructureSection load='2v2e' size='340' side='right' caption='[[2v2e]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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==Structure of isoniazid (INH) bound to cytochrome c peroxidase mutant N184R Y36A==
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<StructureSection load='2v2e' size='340' side='right'caption='[[2v2e]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2v2e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V2E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2v2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V2E FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ISZ:4-(DIAZENYLCARBONYL)PYRIDINE'>ISZ</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a2f|1a2f]], [[1a2g|1a2g]], [[1aa4|1aa4]], [[1ac4|1ac4]], [[1ac8|1ac8]], [[1aeb|1aeb]], [[1aed|1aed]], [[1aee|1aee]], [[1aef|1aef]], [[1aeg|1aeg]], [[1aeh|1aeh]], [[1aej|1aej]], [[1aek|1aek]], [[1aem|1aem]], [[1aen|1aen]], [[1aeo|1aeo]], [[1aeq|1aeq]], [[1aes|1aes]], [[1aet|1aet]], [[1aeu|1aeu]], [[1aev|1aev]], [[1bej|1bej]], [[1bek|1bek]], [[1bem|1bem]], [[1bep|1bep]], [[1beq|1beq]], [[1bes|1bes]], [[1bj9|1bj9]], [[1bva|1bva]], [[1cca|1cca]], [[1ccb|1ccb]], [[1ccc|1ccc]], [[1cce|1cce]], [[1ccg|1ccg]], [[1cci|1cci]], [[1ccj|1ccj]], [[1cck|1cck]], [[1ccl|1ccl]], [[1ccp|1ccp]], [[1cmp|1cmp]], [[1cmq|1cmq]], [[1cmt|1cmt]], [[1cmu|1cmu]], [[1cpd|1cpd]], [[1cpe|1cpe]], [[1cpf|1cpf]], [[1cpg|1cpg]], [[1cyf|1cyf]], [[1dcc|1dcc]], [[1dj1|1dj1]], [[1dj5|1dj5]], [[1ds4|1ds4]], [[1dse|1dse]], [[1dsg|1dsg]], [[1dso|1dso]], [[1dsp|1dsp]], [[1ebe|1ebe]], [[1jci|1jci]], [[1jdr|1jdr]], [[1kok|1kok]], [[1krj|1krj]], [[1kxm|1kxm]], [[1kxn|1kxn]], [[1mk8|1mk8]], [[1mkq|1mkq]], [[1mkr|1mkr]], [[1ml2|1ml2]], [[1ryc|1ryc]], [[1s6v|1s6v]], [[1sdq|1sdq]], [[1sog|1sog]], [[1stq|1stq]], [[1u74|1u74]], [[1u75|1u75]], [[1z53|1z53]], [[1zby|1zby]], [[1zbz|1zbz]], [[2b0z|2b0z]], [[2b10|2b10]], [[2b11|2b11]], [[2b12|2b12]], [[2bcn|2bcn]], [[2ccp|2ccp]], [[2cep|2cep]], [[2cyp|2cyp]], [[2gb8|2gb8]], [[2pcb|2pcb]], [[2pcc|2pcc]], [[2v23|2v23]], [[3ccp|3ccp]], [[3ccx|3ccx]], [[4ccp|4ccp]], [[4ccx|4ccx]], [[5ccp|5ccp]], [[6ccp|6ccp]], [[7ccp|7ccp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ISZ:4-(DIAZENYLCARBONYL)PYRIDINE'>ISZ</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytochrome-c_peroxidase Cytochrome-c peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.5 1.11.1.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2e OCA], [https://pdbe.org/2v2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v2e RCSB], [https://www.ebi.ac.uk/pdbsum/2v2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v2e ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v2e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v2e RCSB], [http://www.ebi.ac.uk/pdbsum/2v2e PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCPR_YEAST CCPR_YEAST] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2e_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v2/2v2e_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v2e ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2v2e" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Cytochrome c peroxidase|Cytochrome c peroxidase]]
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*[[Cytochrome c peroxidase 3D structures|Cytochrome c peroxidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cytochrome-c peroxidase]]
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Brown, K A.]]
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[[Category: Brown KA]]
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[[Category: Macdonald, I K.]]
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[[Category: Macdonald IK]]
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[[Category: Metcalfe, C L.]]
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[[Category: Metcalfe CL]]
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[[Category: Moody, P C.E.]]
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[[Category: Moody PCE]]
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[[Category: Raven, E L.]]
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[[Category: Raven EL]]
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[[Category: Ccp]]
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[[Category: Cytochrome c peroxidase]]
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[[Category: Heme]]
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[[Category: Hydrogen peroxide]]
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[[Category: Inh]]
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[[Category: Iron]]
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[[Category: Isoniazid]]
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[[Category: Metal-binding]]
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[[Category: Mitochondrion]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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[[Category: Transit peptide]]
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Current revision

Structure of isoniazid (INH) bound to cytochrome c peroxidase mutant N184R Y36A

PDB ID 2v2e

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