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3bc3
From Proteopedia
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==Exploring inhibitor binding at the S subsites of cathepsin L== | ==Exploring inhibitor binding at the S subsites of cathepsin L== | ||
| - | <StructureSection load='3bc3' size='340' side='right' caption='[[3bc3]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3bc3' size='340' side='right'caption='[[3bc3]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3bc3]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3bc3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BC3 FirstGlance]. <br> |
| - | </td></tr><tr | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=OPT:S-BENZYL-N-(BIPHENYL-4-YLACETYL)-L-CYSTEINYL-N~5~-(DIAMINOMETHYL)-D-ORNITHYL-N-(2-PHENYLETHYL)-L-TYROSINAMIDE'>OPT</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bc3 OCA], [https://pdbe.org/3bc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bc3 RCSB], [https://www.ebi.ac.uk/pdbsum/3bc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bc3 ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>[[ | + | </table> |
| - | + | == Function == | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | [https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes. |
| - | <table> | + | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/3bc3_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/3bc3_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bc3 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3bc3" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Cathepsin|Cathepsin]] | + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cathepsin L]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bhat | + | [[Category: Large Structures]] |
| - | [[Category: Chowdhury | + | [[Category: Bhat S]] |
| - | [[Category: Joseph | + | [[Category: Chowdhury SF]] |
| - | [[Category: Kumar | + | [[Category: Joseph L]] |
| - | [[Category: Nard | + | [[Category: Kumar S]] |
| - | [[Category: Purisima | + | [[Category: Nard RM]] |
| - | [[Category: Sivaraman | + | [[Category: Purisima EO]] |
| - | [[Category: Tulsidas | + | [[Category: Sivaraman J]] |
| - | [[Category: Ziomek | + | [[Category: Tulsidas SR]] |
| - | + | [[Category: Ziomek E]] | |
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Current revision
Exploring inhibitor binding at the S subsites of cathepsin L
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Categories: Homo sapiens | Large Structures | Bhat S | Chowdhury SF | Joseph L | Kumar S | Nard RM | Purisima EO | Sivaraman J | Tulsidas SR | Ziomek E
