2j63

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==CRYSTAL STRUCTURE OF AP ENDONUCLEASE LMAP FROM LEISHMANIA MAJOR==
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<StructureSection load='2j63' size='340' side='right' caption='[[2j63]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
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==Crystal structure of AP endonuclease LMAP from Leishmania major==
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<StructureSection load='2j63' size='340' side='right'caption='[[2j63]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2j63]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2J63 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2j63]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J63 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-(apurinic_or_apyrimidinic_site)_lyase DNA-(apurinic or apyrimidinic site) lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.99.18 4.2.99.18] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2j63 RCSB], [http://www.ebi.ac.uk/pdbsum/2j63 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j63 OCA], [https://pdbe.org/2j63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j63 RCSB], [https://www.ebi.ac.uk/pdbsum/2j63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j63 ProSAT]</span></td></tr>
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<table>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O15922_LEIMA O15922_LEIMA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j63_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j6/2j63_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j63 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2j63" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Apurinic-Apyrimidinic Endonuclease-1|Apurinic-Apyrimidinic Endonuclease-1]]
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*[[Apurinic/apyrimidinic endonuclease 3D structures|Apurinic/apyrimidinic endonuclease 3D structures]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Leishmania major]]
[[Category: Leishmania major]]
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[[Category: Castillo-Acosta, V M.]]
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[[Category: Castillo-Acosta VM]]
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[[Category: Gallego, C.]]
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[[Category: Gallego C]]
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[[Category: Gonzalez-Pacanowska, D.]]
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[[Category: Gonzalez-Pacanowska D]]
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[[Category: Harkiolaki, M.]]
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[[Category: Harkiolaki M]]
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[[Category: Ruiz-Perez, L M.]]
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[[Category: Ruiz-Perez LM]]
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[[Category: Vidal, A E.]]
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[[Category: Vidal AE]]
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[[Category: Wilson, K S.]]
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[[Category: Wilson KS]]
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[[Category: Base excision repair]]
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[[Category: Endonuclease]]
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[[Category: Leishmania]]
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[[Category: Lyase]]
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Current revision

Crystal structure of AP endonuclease LMAP from Leishmania major

PDB ID 2j63

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