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2iwy

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==HUMAN MITOCHONDRIAL BETA-KETOACYL ACP SYNTHASE==
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<StructureSection load='2iwy' size='340' side='right' caption='[[2iwy]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
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==Human mitochondrial beta-ketoacyl ACP synthase==
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<StructureSection load='2iwy' size='340' side='right'caption='[[2iwy]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2iwy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IWY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2iwy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IWY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IWY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.06&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2c9h|2c9h]], [[2iwz|2iwz]], [[2ix4|2ix4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwy OCA], [https://pdbe.org/2iwy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iwy RCSB], [https://www.ebi.ac.uk/pdbsum/2iwy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iwy ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2iwy RCSB], [http://www.ebi.ac.uk/pdbsum/2iwy PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/OXSM_HUMAN OXSM_HUMAN] May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.<ref>PMID:15668256</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwy_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iwy_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iwy ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2iwy" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Acyl carrier protein synthase|Acyl carrier protein synthase]]
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*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
 
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Christensen, C E.]]
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[[Category: Large Structures]]
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[[Category: Henriksen, A.]]
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[[Category: Christensen CE]]
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[[Category: Kragelund, B B.]]
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[[Category: Henriksen A]]
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[[Category: Wettstein-Knowles, P Von.]]
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[[Category: Kragelund BB]]
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[[Category: Acyltransferase]]
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[[Category: Von Wettstein-Knowles P]]
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[[Category: Beta-ketoacyl acp synthase]]
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[[Category: Cerulenin]]
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[[Category: Claisen condensation]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Fatty acid synthesis]]
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[[Category: Homo sapien]]
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[[Category: Ka]]
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[[Category: Lipid synthesis]]
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[[Category: Mitochondria]]
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[[Category: Mitochondrion]]
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[[Category: Transferase]]
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[[Category: Transit peptide]]
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Current revision

Human mitochondrial beta-ketoacyl ACP synthase

PDB ID 2iwy

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