2wf0
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='2wf0' size='340' side='right' caption='[[2wf0]], [[Resolution|resolution]] 1.60Å' scene=''> | + | ==Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide== |
| + | <StructureSection load='2wf0' size='340' side='right'caption='[[2wf0]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wf0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WF0 FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZY0:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE'>ZY0</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZY0:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-4-ETHYL-8-(2-OXOPYRROLIDIN-1-YL)QUINOLINE-6-CARBOXAMIDE'>ZY0</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf0 OCA], [https://pdbe.org/2wf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2wf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wf0 ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf0_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wf0_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wf0 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2wf0" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Beta secretase|Beta secretase]] | + | *[[Beta secretase 3D structures|Beta secretase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Charrier N]] | |
| - | [[Category: Charrier | + | [[Category: Clarke B]] |
| - | [[Category: Clarke | + | [[Category: Cutler L]] |
| - | [[Category: Cutler | + | [[Category: Demont E]] |
| - | [[Category: Demont | + | [[Category: Dingwall C]] |
| - | [[Category: Dingwall | + | [[Category: Dunsdon R]] |
| - | [[Category: Dunsdon | + | [[Category: Hawkins J]] |
| - | [[Category: Hawkins | + | [[Category: Howes C]] |
| - | [[Category: Howes | + | [[Category: Hubbard J]] |
| - | [[Category: Hubbard | + | [[Category: Hussain I]] |
| - | [[Category: Hussain | + | [[Category: Maile G]] |
| - | [[Category: Maile | + | [[Category: Matico R]] |
| - | [[Category: Matico | + | [[Category: Mosley J]] |
| - | [[Category: Mosley | + | [[Category: Naylor A]] |
| - | [[Category: Naylor | + | [[Category: O'Brien A]] |
| - | [[Category: Redshaw | + | [[Category: Redshaw S]] |
| - | [[Category: Rowland | + | [[Category: Rowland P]] |
| - | [[Category: Smith | + | [[Category: Smith KJ]] |
| - | [[Category: Soleil | + | [[Category: Soleil V]] |
| - | [[Category: Sweitzer | + | [[Category: Sweitzer S]] |
| - | [[Category: Theobald | + | [[Category: Theobald P]] |
| - | [[Category: Vesey | + | [[Category: Vesey D]] |
| - | [[Category: Walter | + | [[Category: Walter DS]] |
| - | [[Category: Wayne | + | [[Category: Wayne G]] |
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Current revision
Human BACE-1 in complex with 4-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-8-(2-oxo-1-pyrrolidinyl)-6-quinolinecarboxamide
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Categories: Homo sapiens | Large Structures | Charrier N | Clarke B | Cutler L | Demont E | Dingwall C | Dunsdon R | Hawkins J | Howes C | Hubbard J | Hussain I | Maile G | Matico R | Mosley J | Naylor A | O'Brien A | Redshaw S | Rowland P | Smith KJ | Soleil V | Sweitzer S | Theobald P | Vesey D | Walter DS | Wayne G
