3jwe
From Proteopedia
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==Crystal structure of human mono-glyceride lipase in complex with SAR629== | ==Crystal structure of human mono-glyceride lipase in complex with SAR629== | ||
| - | <StructureSection load='3jwe' size='340' side='right' caption='[[3jwe]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='3jwe' size='340' side='right'caption='[[3jwe]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3jwe]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JWE FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F4P:1-[BIS(4-FLUOROPHENYL)METHYL]-4-(1H-1,2,4-TRIAZOL-1-YLCARBONYL)PIPERAZINE'>F4P</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jwe OCA], [https://pdbe.org/3jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jwe RCSB], [https://www.ebi.ac.uk/pdbsum/3jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jwe ProSAT]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </table> |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwe_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jw/3jwe_consurf.spt"</scriptWhenChecked> |
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jwe ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3jwe" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Lipase|Lipase]] | + | *[[Lipase 3D Structures|Lipase 3D Structures]] |
*[[Sandbox reserved 916|Sandbox reserved 916]] | *[[Sandbox reserved 916|Sandbox reserved 916]] | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Acylglycerol lipase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Auge | + | [[Category: Large Structures]] |
| - | [[Category: Berne | + | [[Category: Auge F]] |
| - | [[Category: Bertrand | + | [[Category: Berne PF]] |
| - | [[Category: Cheuret | + | [[Category: Bertrand T]] |
| - | [[Category: Hoornaert | + | [[Category: Cheuret D]] |
| - | [[Category: Houtmann | + | [[Category: Hoornaert C]] |
| - | [[Category: Mathieu | + | [[Category: Houtmann J]] |
| - | [[Category: Michot | + | [[Category: Mathieu M]] |
| - | [[Category: Mikol | + | [[Category: Michot N]] |
| - | [[Category: Rak | + | [[Category: Mikol V]] |
| - | [[Category: Vallee | + | [[Category: Rak A]] |
| - | + | [[Category: Vallee F]] | |
| - | + | ||
Current revision
Crystal structure of human mono-glyceride lipase in complex with SAR629
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Categories: Homo sapiens | Large Structures | Auge F | Berne PF | Bertrand T | Cheuret D | Hoornaert C | Houtmann J | Mathieu M | Michot N | Mikol V | Rak A | Vallee F
