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3fv7

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==OXA-24 beta-lactamase complex with SA4-44 inhibitor==
==OXA-24 beta-lactamase complex with SA4-44 inhibitor==
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<StructureSection load='3fv7' size='340' side='right' caption='[[3fv7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3fv7' size='340' side='right'caption='[[3fv7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fv7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FV7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FV7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MXS:(2S)-2-[[2-METHANOYL-7-(METHOXYCARBONYLAMINO)INDOLIZIN-3-YL]AMINO]-3-METHYL-3-SULFINO-BUTANOIC+ACID'>MXS</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=MXS:(2S)-2-[[2-METHANOYL-7-(METHOXYCARBONYLAMINO)INDOLIZIN-3-YL]AMINO]-3-METHYL-3-SULFINO-BUTANOIC+ACID'>MXS</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaOXA-33, bla-OXA-40, oxa-24, oxa40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=470 Acinetobacter baumannii])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fv7 OCA], [https://pdbe.org/3fv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fv7 RCSB], [https://www.ebi.ac.uk/pdbsum/3fv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fv7 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fv7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fv7 RCSB], [http://www.ebi.ac.uk/pdbsum/3fv7 PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/Q8RLA6_ACIBA Q8RLA6_ACIBA]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fv7_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/3fv7_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fv7 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3fv7" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Acinetobacter baumannii]]
[[Category: Acinetobacter baumannii]]
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[[Category: Beta-lactamase]]
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[[Category: Large Structures]]
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[[Category: Akker, F Van den.]]
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[[Category: Beceiro A]]
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[[Category: Beceiro, A.]]
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[[Category: Bethel CR]]
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[[Category: Bethel, C R.]]
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[[Category: Bonomo RA]]
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[[Category: Bonomo, R A.]]
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[[Category: Bou G]]
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[[Category: Bou, G.]]
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[[Category: Buynak JD]]
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[[Category: Buynak, J D.]]
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[[Category: Distler AM]]
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[[Category: Distler, A M.]]
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[[Category: Drawz SM]]
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[[Category: Drawz, S M.]]
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[[Category: Kalp M]]
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[[Category: Kalp, M.]]
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[[Category: Pagadala SR]]
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[[Category: Pagadala, S R.]]
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[[Category: Romero A]]
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[[Category: Romero, A.]]
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[[Category: Sampson JM]]
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[[Category: Sampson, J M.]]
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[[Category: Santillana E]]
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[[Category: Santillana, E.]]
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[[Category: Sheri A]]
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[[Category: Sheri, A.]]
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[[Category: Van den Akker F]]
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[[Category: B-lactamase]]
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[[Category: Carbapenem]]
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[[Category: Enzyme mechanism]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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Current revision

OXA-24 beta-lactamase complex with SA4-44 inhibitor

PDB ID 3fv7

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