3drw

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==Crystal Structure of a Phosphofructokinase from Pyrococcus horikoshii OT3 with AMP==
==Crystal Structure of a Phosphofructokinase from Pyrococcus horikoshii OT3 with AMP==
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<StructureSection load='3drw' size='340' side='right' caption='[[3drw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='3drw' size='340' side='right'caption='[[3drw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3drw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DRW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3drw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DRW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u2x|1u2x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pfkC, PH1645 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=53953 Pyrococcus horikoshii])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3drw OCA], [https://pdbe.org/3drw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3drw RCSB], [https://www.ebi.ac.uk/pdbsum/3drw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3drw ProSAT], [https://www.topsan.org/Proteins/MCSG/3drw TOPSAN]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-specific_phosphofructokinase ADP-specific phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.146 2.7.1.146] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3drw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3drw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3drw RCSB], [http://www.ebi.ac.uk/pdbsum/3drw PDBsum], [http://www.topsan.org/Proteins/MCSG/3drw TOPSAN]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/K6PF_PYRHO K6PF_PYRHO] Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3drw_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/3drw_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3drw ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3drw" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
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*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ADP-specific phosphofructokinase]]
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[[Category: Large Structures]]
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[[Category: Pyrococcus horikoshii]]
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[[Category: Brown, G.]]
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[[Category: Cuff, M E.]]
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[[Category: Edwards, A M.]]
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[[Category: Jia, Z.]]
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[[Category: Joachimiak, A.]]
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[[Category: Kochinyan, S.]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Savchenko, A.]]
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[[Category: Singer, A U.]]
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[[Category: Skarina, T.]]
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[[Category: Yakunin, A F.]]
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[[Category: 6-phosphofructokinase]]
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[[Category: Adp]]
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[[Category: Amp]]
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[[Category: Glycolysis]]
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[[Category: Kinase]]
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[[Category: Magnesium]]
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[[Category: Mcsg]]
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[[Category: Metal-binding]]
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[[Category: Midwest center for structural genomic]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Pyrococcus horikoshii]]
[[Category: Pyrococcus horikoshii]]
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[[Category: Structural genomic]]
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[[Category: Brown G]]
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[[Category: Transferase]]
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[[Category: Cuff ME]]
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[[Category: Edwards AM]]
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[[Category: Jia Z]]
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[[Category: Joachimiak A]]
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[[Category: Kochinyan S]]
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[[Category: Savchenko A]]
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[[Category: Singer AU]]
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[[Category: Skarina T]]
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[[Category: Yakunin AF]]

Current revision

Crystal Structure of a Phosphofructokinase from Pyrococcus horikoshii OT3 with AMP

PDB ID 3drw

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