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1odc
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1odc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ODC FirstGlance]. <br> | <table><tr><td colspan='2'>[[1odc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ODC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ODC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8B:N-QUINOLIN-4-YL-N-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE'>A8B</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8B:N-QUINOLIN-4-YL-N-(1,2,3,4-TETRAHYDROACRIDIN-9-YL)OCTANE-1,8-DIAMINE'>A8B</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zgb|1zgb]], [[1amn|1amn]], [[1qti|1qti]], [[1e66|1e66]], [[2j3d|2j3d]], [[2vq6|2vq6]], [[2ack|2ack]], [[1qii|1qii]], [[2ckm|2ckm]], [[1dx6|1dx6]], [[1qie|1qie]], [[1qij|1qij]], [[1acl|1acl]], [[1w4l|1w4l]], [[2cmf|2cmf]], [[2wg0|2wg0]], [[1gqs|1gqs]], [[2j3q|2j3q]], [[1e3q|1e3q]], [[2j4f|2j4f]], [[1qik|1qik]], [[2dfp|2dfp]], [[2c5f|2c5f]], [[1ea5|1ea5]], [[1eea|1eea]], [[2vjc|2vjc]], [[1qif|1qif]], [[2vjb|2vjb]], [[1qig|1qig]], [[1zgc|1zgc]], [[1qid|1qid]], [[2wfz|2wfz]], [[1jjb|1jjb]], [[2vjd|2vjd]], [[1ut6|1ut6]], [[2wg1|2wg1]], [[2vt6|2vt6]], [[2w9i|2w9i]], [[2wg2|2wg2]], [[2vt7|2vt7]], [[2cek|2cek]], [[1qim|1qim]], [[1gpk|1gpk]], [[1jga|1jga]], [[3ace|3ace]], [[1w6r|1w6r]], [[1oce|1oce]], [[1som|1som]], [[1vxo|1vxo]], [[2w6c|2w6c]], [[2vja|2vja]], [[1cfj|1cfj]], [[2v96|2v96]], [[1u65|1u65]], [[1ax9|1ax9]], [[1w76|1w76]], [[1h22|1h22]], [[1eve|1eve]], [[2c4h|2c4h]], [[2va9|2va9]], [[1gqr|1gqr]], [[2ace|2ace]], [[1vxr|1vxr]], [[4ace|4ace]], [[2c58|2c58]], [[1hbj|1hbj]], [[1vot|1vot]], [[1w75|1w75]], [[2c5g|2c5g]], [[1jgb|1jgb]], [[2v98|2v98]], [[1gpn|1gpn]], [[1qih|1qih]], [[2vb4|2vb4]], [[1h23|1h23]], [[1acj|1acj]], [[1fss|1fss]], [[2v97|2v97]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zgb|1zgb]], [[1amn|1amn]], [[1qti|1qti]], [[1e66|1e66]], [[2j3d|2j3d]], [[2vq6|2vq6]], [[2ack|2ack]], [[1qii|1qii]], [[2ckm|2ckm]], [[1dx6|1dx6]], [[1qie|1qie]], [[1qij|1qij]], [[1acl|1acl]], [[1w4l|1w4l]], [[2cmf|2cmf]], [[2wg0|2wg0]], [[1gqs|1gqs]], [[2j3q|2j3q]], [[1e3q|1e3q]], [[2j4f|2j4f]], [[1qik|1qik]], [[2dfp|2dfp]], [[2c5f|2c5f]], [[1ea5|1ea5]], [[1eea|1eea]], [[2vjc|2vjc]], [[1qif|1qif]], [[2vjb|2vjb]], [[1qig|1qig]], [[1zgc|1zgc]], [[1qid|1qid]], [[2wfz|2wfz]], [[1jjb|1jjb]], [[2vjd|2vjd]], [[1ut6|1ut6]], [[2wg1|2wg1]], [[2vt6|2vt6]], [[2w9i|2w9i]], [[2wg2|2wg2]], [[2vt7|2vt7]], [[2cek|2cek]], [[1qim|1qim]], [[1gpk|1gpk]], [[1jga|1jga]], [[3ace|3ace]], [[1w6r|1w6r]], [[1oce|1oce]], [[1som|1som]], [[1vxo|1vxo]], [[2w6c|2w6c]], [[2vja|2vja]], [[1cfj|1cfj]], [[2v96|2v96]], [[1u65|1u65]], [[1ax9|1ax9]], [[1w76|1w76]], [[1h22|1h22]], [[1eve|1eve]], [[2c4h|2c4h]], [[2va9|2va9]], [[1gqr|1gqr]], [[2ace|2ace]], [[1vxr|1vxr]], [[4ace|4ace]], [[2c58|2c58]], [[1hbj|1hbj]], [[1vot|1vot]], [[1w75|1w75]], [[2c5g|2c5g]], [[1jgb|1jgb]], [[2v98|2v98]], [[1gpn|1gpn]], [[1qih|1qih]], [[2vb4|2vb4]], [[1h23|1h23]], [[1acj|1acj]], [[1fss|1fss]], [[2v97|2v97]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1odc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1odc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1odc RCSB], [http://www.ebi.ac.uk/pdbsum/1odc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1odc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1odc OCA], [http://pdbe.org/1odc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1odc RCSB], [http://www.ebi.ac.uk/pdbsum/1odc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1odc ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1odc" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[AChE | + | *[[AChE inhibitors and substrates|AChE inhibitors and substrates]] |
| - | + | ||
*[[Acetylcholinesterase complexed with N-9-(1'%2C2'%2C3'%2C4'-tetrahydroacridinyl)-1%2C8-diaminooctane|Acetylcholinesterase complexed with N-9-(1'%2C2'%2C3'%2C4'-tetrahydroacridinyl)-1%2C8-diaminooctane]] | *[[Acetylcholinesterase complexed with N-9-(1'%2C2'%2C3'%2C4'-tetrahydroacridinyl)-1%2C8-diaminooctane|Acetylcholinesterase complexed with N-9-(1'%2C2'%2C3'%2C4'-tetrahydroacridinyl)-1%2C8-diaminooctane]] | ||
*[[Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (5 carbon linker)|Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (5 carbon linker)]] | *[[Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (5 carbon linker)|Torpedo californica acetylcholinesterase with alkylene-linked tacrine dimer (5 carbon linker)]] | ||
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*[[User:Boris Brumshtein|User:Boris Brumshtein]] | *[[User:Boris Brumshtein|User:Boris Brumshtein]] | ||
*[[User:Dawn M. Wong|User:Dawn M. Wong]] | *[[User:Dawn M. Wong|User:Dawn M. Wong]] | ||
| + | *[[3D structures of acetylcholinesterase|3D structures of acetylcholinesterase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: Torpedo californica]] | [[Category: Torpedo californica]] | ||
| - | [[Category: Carlier, P R | + | [[Category: Carlier, P R]] |
| - | [[Category: Greenblatt, H M | + | [[Category: Greenblatt, H M]] |
| - | [[Category: Han, Y F | + | [[Category: Han, Y F]] |
| - | [[Category: Pang, Y P | + | [[Category: Pang, Y P]] |
| - | [[Category: Silman, I | + | [[Category: Silman, I]] |
| - | [[Category: Sussman, J L | + | [[Category: Sussman, J L]] |
| - | [[Category: Wong, D M | + | [[Category: Wong, D M]] |
[[Category: Alzheimer's disease]] | [[Category: Alzheimer's disease]] | ||
[[Category: Bivalent ligand]] | [[Category: Bivalent ligand]] | ||
Current revision
STRUCTURE OF ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH N-4'-QUINOLYL-N'-9"-(1",2",3",4" -TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE AT 2.2A RESOLUTION
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Categories: Acetylcholinesterase | Torpedo californica | Carlier, P R | Greenblatt, H M | Han, Y F | Pang, Y P | Silman, I | Sussman, J L | Wong, D M | Alzheimer's disease | Bivalent ligand | Dual-site binding | Glycoprotein | Gpi-anchor neurotransmitter degradation | Hydrolase | Inhibitor | Muscle | Nerve | Neurotransmitter cleavage | Serine esterase synapse | Serine hydrolase
