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1h5b

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[[Image:1h5b.jpg|left|200px]]
 
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{{Structure
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==T cell receptor Valpha11 (AV11S5) domain==
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|PDB= 1h5b |SIZE=350|CAPTION= <scene name='initialview01'>1h5b</scene>, resolution 1.85&Aring;
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<StructureSection load='1h5b' size='340' side='right'caption='[[1h5b]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[1h5b]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H5B FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h5b OCA], [https://pdbe.org/1h5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h5b RCSB], [https://www.ebi.ac.uk/pdbsum/1h5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h5b ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/1h5b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h5b ConSurf].
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<div style="clear:both"></div>
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'''T CELL RECEPTOR VALPHA11 (AV11S5) DOMAIN'''
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==See Also==
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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We describe the X-ray crystallographic structure of a murine T cell receptor (TCR) Valpha domain ("Valpha85.33"; AV11S5-AJ17) to 1.85 A resolution. The Valpha85.33 domain is derived from a TCR that recognizes a type II collagen peptide associated with the murine major histocompatibility complex (MHC) class II molecule, I-A(q). Valpha85.33 packs as a Valpha-Valpha homodimer with a highly symmetric monomer-monomer interface. The first and second complementarity determining regions (CDR1 and CDR2) of this Valpha are shorter than the CDRs corresponding to the majority of other Valpha gene families, and three-dimensional structures of CDRs of these lengths have not been described previously. The CDR1 and CDR2 therefore represent new canonical forms that could serve as templates for AV11 family members. CDR3 of the Valpha85.33 domain is highly flexible and this is consistent with plasticity of this region of the TCR. The fourth hypervariable loop (HV4alpha) of AV11 and AV10 family members is one residue longer than that of other HV4alpha regions and shows a high degree of flexibility. The increase in length results in a distinct disposition of the conserved residue Lys68, which has been shown in other studies to play a role in antigen recognition. The X-ray structure of Valpha85.33 extends the database of canonical forms for CDR1 and CDR2, and has implications for antigen recognition by TCRs that contain related Valpha domains.
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[[Category: Large Structures]]
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==About this Structure==
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1H5B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H5B OCA].
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==Reference==
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Crystal structure of a T cell receptor Valpha11 (AV11S5) domain: new canonical forms for the first and second complementarity determining regions., Machius M, Cianga P, Deisenhofer J, Ward ES, J Mol Biol. 2001 Jul 20;310(4):689-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11453680 11453680]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Cianga P]]
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[[Category: Cianga, P.]]
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[[Category: Deisenhofer J]]
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[[Category: Deisenhofer, J.]]
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[[Category: Machius M]]
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[[Category: Machius, M.]]
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[[Category: Sally Ward E]]
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[[Category: Ward, E S.]]
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[[Category: CL]]
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[[Category: GOL]]
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[[Category: immune response]]
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[[Category: immunoglobulin fold]]
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[[Category: t cell receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:32:27 2008''
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Current revision

T cell receptor Valpha11 (AV11S5) domain

PDB ID 1h5b

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